Contribution of Carotid Bodies on Pulmonary Function During Normoxia and Acute Hypoxia

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dc.article.numbere00798
dc.contributor.authorSchwarz K.G.
dc.contributor.authorFlores M.
dc.contributor.authorVoituron N.
dc.contributor.authorDel Rio R.
dc.date.accessioned2025-05-01T10:31:17Z
dc.date.available2025-05-01T10:31:17Z
dc.date.issued2023
dc.description.abstract© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.Carotid bodies (CBs) are main peripheral chemoreceptors involved in breathing regulation. Despite the well-known role played by CBs on breathing control, the precise contribution of CBs on the regulation of lung mechanics remains controversial. Accordingly, we study changes in lung mechanics in normoxia (FiO2 21%) and hypoxia (FiO2 8%) in mice with or without functional CBs. For this, we used adult male mice that underwent sham or CB denervation (CBD) surgery. Compared to sham-operated mice, we found that CBD induced an increase in lung resistance (RL) while breathing normoxic air (sham vs. CBD, p < 0.05). Importantly, changes in RL were accompanied by an approximately threefold reduction in dynamic compliance (Cdyn). Additionally, end-expiratory work (EEW) was increased in normoxia in the CBD group. Contrarily, we found that CBD has no effect on lung mechanics during hypoxic stimulation. Indeed, RL, Cdyn, and EEW values in CBD mice were undistinguishable from the ones obtained in sham mice. Finally, we found that CBD induces lung parenchyma morphological alterations characterized by reduced alveoli space. Together our results showed that CBD progressively increases lung resistance at normoxic conditions and suggest that CB tonic afferent discharges are needed for the proper regulation of lung mechanics at rest.
dc.description.funderANID-FONDECYT
dc.description.funderCEDENNA
dc.format.extent13 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1007/978-3-031-32371-3_14
dc.identifier.eisbn978-1-5106-5352-8
dc.identifier.eissn1542-7714
dc.identifier.isbn978-1-5106-5351-1
dc.identifier.issn00652598
dc.identifier.pubmedid40243597
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85163905351
dc.identifier.urihttps://doi.org/10.1007/978-3-031-32371-3_14
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103736
dc.identifier.wosidWOS:001159473800015
dc.information.autorucFacultad de Ciencias Biológicas; Del Rio Troncoso Rodrigo Andre; 0000-0003-0315-6660; 126608
dc.issue.numero8
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final134
dc.pagina.inicio127
dc.relation.ispartofInternational Conference on Intelligent User Interfaces (30a. : 2025)
dc.revistaAdvances in experimental medicine and biology
dc.rightsacceso restringido
dc.subjectCarotid body
dc.subjectCarotid body denervation
dc.subjectDynamic compliance
dc.subjectHypoxia
dc.subjectLung resistance
dc.subjectNormoxia
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleContribution of Carotid Bodies on Pulmonary Function During Normoxia and Acute Hypoxia
dc.typeartículo
dc.volumen1427
sipa.codpersvinculados126608
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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