HUMAN LACTATIONAL RESPONSE TO ORAL THYROTROPIN RELEASING HORMONE

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dc.contributor.authorTYSON, JE
dc.contributor.authorPEREZ, A
dc.contributor.authorZANARTU, J
dc.date.accessioned2025-01-23T19:45:02Z
dc.date.available2025-01-23T19:45:02Z
dc.date.issued1976
dc.description.abstractSeveral studies were designed to evaluate the effect of oral TRH [thyrotropin releasing hormone] on prolactin (PRL) secretion and mammary function in nursing women. Initially efficacy was studied in nursing women following 5 mg TRH. PRL levels rose to a mean maximum of 46.3 ng/ml above baseline at 60 min. Plasma TSH also increased from a mean baseline of 2.6 to 17.6 .mu.U/ml at 180 min. No changes were observed following placebo. In order to observe the long term effects of oral TRH, 2 groups of women in full nursing were studied. Beginning on day 29 postpartum, either 5 mg TRH or placebo were taken twice daily for 4 wk. No chronic elevations were observed in maternal PRL and TSH or in infant TSH before or after 1 mo. of either regimen. Milk composition expressed in terms of per cent protein and per cent fat did not differ between the groups. Weekly gonadotropin levels were also similar as were infant weight gain and growth. In a group of women with lactational insufficiency receiving 5-20 mg TRH twice daily for 5 days, basal PRL concentrations markedly increased. While changes in milk composition were not significant, fat percentages increased slightly and protein percentages declined. Breast engorgement and milk letdown increased and full nursing was restored. While the oral TRH used in fully nursing women had no demonstrable effect on mammary function, it may prove useful in those women with lactational insufficiency. Because 2 women developed iatrogenic hyperthyroidism following 40 mg oral TRH twice daily, care must be exercised in determining the dosage to be employed.
dc.fuente.origenWOS
dc.identifier.eissn1945-7197
dc.identifier.issn0021-972X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100190
dc.identifier.wosidWOS:A1976CH75000006
dc.issue.numero4
dc.language.isoen
dc.pagina.final768
dc.pagina.inicio760
dc.revistaJournal of clinical endocrinology & metabolism
dc.rightsacceso restringido
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleHUMAN LACTATIONAL RESPONSE TO ORAL THYROTROPIN RELEASING HORMONE
dc.typeartículo
dc.volumen43
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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