Complete sequence of the genome of the human isolate of Andes virus CHI-7913

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dc.contributor.authorTischler, ND
dc.contributor.authorFernández, J
dc.contributor.authorMüller, I
dc.contributor.authorMartínez, R
dc.contributor.authorGaleno, H
dc.contributor.authorVillagra, E
dc.contributor.authorMora, J
dc.contributor.authorRamírez, E
dc.contributor.authorRosemblatt, M
dc.contributor.authorValenzuela, PDT
dc.date.accessioned2025-01-21T01:09:55Z
dc.date.available2025-01-21T01:09:55Z
dc.date.issued2003
dc.description.abstractWe report here the complete genomic sequence of the Chilean human isolate of Andes virus CHI-7913. The S, M. and L genome segment sequences of this isolate are 1,802, 3,641 and 6,466 bases in length, with an overall GC content of 38.7%. These genome segments code for a nucleocapsid protein of 428 amino acids, a glycoprotein precursor protein of 1,138 amino acids and a RNA-dependent RNA polymerase of 2,152 amino acids. In addition, the genome also has other ORFs coding for putative proteins of 34 to 103 amino acids. The encoded proteins have greater than 98% overall similarity with the proteins of Andes virus isolates AH-1 and Chile R123. Among other sequenced Hantavirus, CHI-7913 is more closely related to Sin Nombre virus, with an overall protein similarity of 92%. The characteristics of the encoded proteins of this isolate, such as hydrophobic domains, glycosylation sites, and conserved amino acid motifs shared with other Hantavirus and other members of the Bunyaviridae family, are identified and discussed.
dc.fuente.origenWOS
dc.identifier.eissn0717-6287
dc.identifier.issn0716-9760
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96633
dc.identifier.wosidWOS:000185322300011
dc.issue.numero2
dc.language.isoen
dc.pagina.final210
dc.pagina.inicio201
dc.revistaBiological research
dc.rightsacceso restringido
dc.subjectHantavirus
dc.subjectgenome sequence
dc.subjectRNA polymerase
dc.subjecthuman isolate
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleComplete sequence of the genome of the human isolate of Andes virus CHI-7913
dc.typeartículo
dc.volumen36
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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