Assessing field cancerization and actinic keratosis using ultraviolet-induced fluorescence dermatoscopy after the application of 5-aminolevulinic acid - An observational study

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dc.contributor.authorKorecka, Katarzyna
dc.contributor.authorPolanska, Adriana
dc.contributor.authorDanczak-Pazdrowska, Aleksandra
dc.contributor.authorNavarrete-Dechent, Cristian
dc.date.accessioned2025-01-20T16:19:20Z
dc.date.available2025-01-20T16:19:20Z
dc.date.issued2024
dc.description.abstractBackground: Actinic keratoses (AK) are one of the most frequent reasons for consultations in dermatology. Ultraviolet-induced fluorescence dermatoscopy (UVFD) is a new method that allows the assessment of lesions in a spectrum of light that originates from the fluorochromes emitting UV-excited luminescence. The aim of this study was to assess the UVFD features of AKs before PDT and their intensity in field cancerization and single lesions. Methods: This retrospective study was conducted from June to November 2023. Lesions were assessed with the Olsen scale clinically and dermatoscopically (DermLite DL5, 10x magnification) and photographed. UVFD fluorescence was categorized as 'none', 'weak', 'moderate', and 'intense'. A 1-mm thick layer of 10 % 5-ALA gel was applied to single lesions or cancerization field (depending on the patient) and covered with an occlusive dressing for 3 h. Prior the application of 10 % 5-ALA gel, the lesions were degreased with an alcoholic solution. The occlusion was removed, and the field was cleaned with a 0,9 % saline solution. Afterward, each lesion was photographed in polarized light and UVFD mode. Results: A total of 194 dermatoscopic images were analyzed, 111 corresponded to field cancerization and 81 to single AKs. Overall, weak fluorescence was noticed in 22 of them (11,3 %), moderate in 107 (55,15 %), and intense in 65 (33,5 %). Amongst field cancerization (111 images), weak fluorescence was seen in 11 (9.9 %), moderate in 68 (61,26 %), and intense in 32 (28,82 %). In single lesions (81 images), weak fluorescence was detected in 11 (13,2 %), moderate in 39 (46,99 %), and intense in 33 (28.83 %) of the lesions. Slightly more intense fluorescence was noticed in higher Olsen grade (p = 0.04). Conclusions: UVFD can enhance our efficacy of pre-procedural examination and might arise as a useful device to predict the therapeutic effect of PDT.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.pdpdt.2024.104056
dc.identifier.eissn1873-1597
dc.identifier.issn1572-1000
dc.identifier.urihttps://doi.org/10.1016/j.pdpdt.2024.104056
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90686
dc.identifier.wosidWOS:001215415000001
dc.language.isoen
dc.revistaPhotodiagnosis and photodynamic therapy
dc.rightsacceso restringido
dc.subjectDermatoscopy
dc.subjectUltraviolet -induced fluorescence dermatoscopy
dc.subjectActinic keratosis
dc.subjectPhotodynamic therapy
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssessing field cancerization and actinic keratosis using ultraviolet-induced fluorescence dermatoscopy after the application of 5-aminolevulinic acid - An observational study
dc.typeartículo
dc.volumen46
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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