Acute ventilatory and circulatory reactions evoked by nicotine

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dc.contributor.authorFernández, R
dc.contributor.authorLarraín, C
dc.contributor.authorZapata, P
dc.date.accessioned2025-01-21T01:10:15Z
dc.date.available2025-01-21T01:10:15Z
dc.date.issued2002
dc.description.abstractEither excitatory or inhibitory cardio-respiratory responses induced by nicotine have been reported. We evaluated the joint and separate contributions of peripheral arterial chemoreceptors and pulmonary vagal afferences to nicotine-induced cardio-respiratory responses in 11 pentobarbitone-anaesthetized cats. Nicotine, given i.v. in doses of from 1 to 200 mug/kg, evoked dose-dependent transient increases in tidal volume (VT) and arterial blood pressure (BP), but the highest doses evoked brief apnoea, immediately followed by intense hyperventilation, as well as discrete early hypotension followed by late hypertension. Bilateral section of the aortic and carotid nerves abolished all hyperventilatory responses to nicotine, giving way to apnoea followed by few cycles of reduced VT and profound hypotension followed by slight hypertension in response to intermediate doses (50-100 mug/kg). Subsequent bilateral vagotomy (BV) suppressed apnoeic and hypotensive responses. In other cats initially subjected to BV, only increases in VT and BP were observed in response to nicotine, effects which were no longer observed after additional carotid and aortic deafferentation. These data suggest that excitatory effects of nicotine on respiration and BP are reflexes evoked by stimulation of peripheral arterial chemoreceptors, while inhibitory effects are also reflex responses but evoked from stimulation of pulmonary vagal afferences. (C) 2002 Elsevier Science B. V. All rights reserved.
dc.fuente.origenWOS
dc.identifier.issn1569-9048
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96666
dc.identifier.wosidWOS:000179446000001
dc.issue.numero3
dc.language.isoen
dc.pagina.final182
dc.pagina.inicio173
dc.revistaRespiratory physiology & neurobiology
dc.rightsacceso restringido
dc.subjectchemoreceptors, arterial, peripheral
dc.subjectcontrol of breathing, ventilatory depression, nicotine
dc.subjectdrugs, nictotine, cardiorespiratory
dc.subjectresponses
dc.subjectmammals, cat
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAcute ventilatory and circulatory reactions evoked by nicotine
dc.typeartículo
dc.volumen133
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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