Photo-induced protein oxidation: mechanisms, consequences and medical applications

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dc.catalogadorgjm
dc.contributor.authorFuentes Lemus, Eduardo Felipe
dc.contributor.authorLópez Alarcón, Camilo Ignacio
dc.date.accessioned2024-12-30T14:34:05Z
dc.date.available2024-12-30T14:34:05Z
dc.date.issued2020
dc.description.abstractIrradiation from the sun has played a crucial role in the origin and evolution of life on the earth. Due to the presence of ozone in the stratosphere most of the hazardous irradiation is absorbed, nonetheless UVB, UVA, and visible light reach the earth's surface. The high abundance of proteins in most living organisms, and the presence of chromophores in the side chains of certain amino acids, explain why these macromolecules are principal targets when biological systems are illuminated. Light absorption triggers the formation of excited species that can initiate photo-modification of proteins. The major pathways involve modifications derived from direct irradiation and photo-sensitized reactions. In this review we explored the basic concepts behind these photochemical pathways, with special emphasis on the photosensitized mechanisms (type 1 and type 2) leading to protein oxidation, and how this affects protein structure and functions. Finally, a description of the photochemical reactions involved in some human diseases, and medical applications of protein oxidation are presented.
dc.description.funderFondecyt
dc.description.funderFondequip
dc.description.funderDICYT
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1042/EBC20190044
dc.identifier.eissn1744-1358
dc.identifier.issn0071-1365
dc.identifier.pubmedidMEDLINE:31845743
dc.identifier.urihttps://doi.org/10.1042/EBC20190044
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89360
dc.identifier.wosidWOS:000537063700003
dc.information.autorucEscuela de Química; Fuentes Lemus, Eduardo Felipe; 0000-0002-1465-8466; 186720
dc.information.autorucEscuela de Química; López Alarcón, Camilo Ignacio; S/I; 1004308
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final44
dc.pagina.inicio33
dc.revistaEssays in Biochemistry
dc.rightsacceso restringido
dc.subjectPhotochemistry
dc.subjectPhotosensitization
dc.subjectProtein crosslinking
dc.subjectProtein oxidation
dc.subjectSinglet oxygen
dc.subjectType 1 mechanism
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePhoto-induced protein oxidation: mechanisms, consequences and medical applications
dc.typeartículo de revisión
dc.volumen64
sipa.codpersvinculados186720
sipa.codpersvinculados1004308
sipa.trazabilidadWOS;05-06-2021
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