Exploring causal mechanisms of psychosis risk

Simple item page
dc.contributor.authorOliver, Dominic
dc.contributor.authorChesney, Edward
dc.contributor.authorCullen, Alexis E.
dc.contributor.authorDavies, Cathy
dc.contributor.authorEnglund, Amir
dc.contributor.authorGifford, George
dc.contributor.authorKerins, Sarah
dc.contributor.authorLalousis, Paris Alexandros
dc.contributor.authorLogeswaran, Yanakan
dc.contributor.authorMerritt, Kate
dc.contributor.authorZahid, Uzma
dc.contributor.authorCrossley, Nicolas A.
dc.contributor.authorMcCutcheon, Robert A.
dc.contributor.authorMcGuire, Philip
dc.contributor.authorFusar-Poli, Paolo
dc.date.accessioned2025-01-20T16:16:18Z
dc.date.available2025-01-20T16:16:18Z
dc.date.issued2024
dc.description.abstractRobust epidemiological evidence of risk and protective factors for psychosis is essential to inform preventive interventions. Previous evidence syntheses have classified these risk and protective factors according to their strength of association with psychosis. In this critical review we appraise the distinct and overlapping mechanisms of 25 key environmental risk factors for psychosis, and link these to mechanistic pathways that may contribute to neurochemical alterations hypothesised to underlie psychotic symptoms. We then discuss the implications of our findings for future research, specifically considering interactions between factors, exploring universal and subgroup-specific factors, improving understanding of temporality and risk dynamics, standardising operationalisation and measurement of risk and protective factors, and developing preventive interventions targeting risk and protective factors.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.neubiorev.2024.105699
dc.identifier.eissn1873-7528
dc.identifier.issn0149-7634
dc.identifier.urihttps://doi.org/10.1016/j.neubiorev.2024.105699
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90540
dc.identifier.wosidWOS:001241526300001
dc.language.isoen
dc.revistaNeuroscience and biobehavioral reviews
dc.rightsacceso restringido
dc.subjectPsychosis
dc.subjectPrevention
dc.subjectRisk factors
dc.subjectNeurobiology
dc.subjectNeurodevelopment
dc.subjectDopamine
dc.subjectGlutamate
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExploring causal mechanisms of psychosis risk
dc.typeartículo
dc.volumen162
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Exploring causal mechanisms of psychosis risk.pdf
Size:
1.78 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas