Arsenic in drinking water and breast cancer: a case-control study from a high exposure area in Northern Chile

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dc.article.number839
dc.catalogadorcarga
dc.contributor.authorBlanco, Estela
dc.contributor.authorAcevedo, Johanna
dc.contributor.authorPerez, Liliana
dc.contributor.authorHerrera, Marian
dc.contributor.authorDuran, Viviana
dc.contributor.authorBarlaro, Teresa
dc.contributor.authorMeza, Rodrigo
dc.contributor.authorRoa, Juan Carlos
dc.contributor.authorParra, Roxana
dc.contributor.authorBenitez, Hugo
dc.contributor.authorSchwalb, Molly E.
dc.contributor.authorSteinmaus, Craig
dc.contributor.authorFerreccio, Catterina
dc.date.accessioned2025-12-15T10:30:24Z
dc.date.available2025-12-15T10:30:24Z
dc.date.issued2025
dc.description.abstractPurpose Exposure to arsenic in drinking water is a cause of lung, bladder, and skin cancer, however the relation between arsenic and breast cancer is unclear. Northern Chile had high levels of arsenic in drinking water (up to 900 mu g/l) between 1950 and 1970, facilitating the study of outcomes with long latency. We conducted a breast cancer case-control study in Northern Chile (2014-2018) and analyzed 505 incident breast cancer cases and 409 population-based female controls with data collected on lifetime exposure to arsenic and potential confounders. Methods We identified cases in collaboration with cancer committees, hospitals, and medical facilities in the study area. Controls were recruited from the Chile Voter Registry. Logistic regression was used to assess the relationship between arsenic exposure and breast cancer adjusting for education and age. We evaluated cumulative, lifetime average and highest single year exposure with tertiles and quartiles and population weighted controls based on age and region of residence. Results Exposure levels were high in both cases and controls, with median (interquartile range) values of: 52 (15-84) and 42 (10-106) mu g/L for average lifetime concentration, respectively. Adjusted odds ratios (OR) for tertile of cumulative exposure to arsenic concentrations in water (< 1.17, 1.17-5.16, and >= 5.17 mg) were 1.00, 0.85 [95% confidence interval (CI), 0.60-1.18], and 1.10 (0.79-1.55). Results were similar for lifetime average and single-highest year exposure metrics. Conclusion We did not find evidence of increased odds of higher arsenic exposure among incident breast cancer cases compared to female population controls.
dc.description.funderNational Agency for Research and Development
dc.description.funderReloncaví Health Service
dc.description.funderUC
dc.description.funderANID
dc.description.funderANID
dc.format.extent28 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1007/s10549-025-07765-9
dc.identifier.eissn1573-7217
dc.identifier.issn0167-6806
dc.identifier.scopusidSCOPUS_ID:105010095345
dc.identifier.urihttps://doi.org/10.1007/s10549-025-07765-9
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107402
dc.identifier.wosidWOS:001524911500001
dc.information.autorucEscuela de Medicina; Blanco, Estela; S/I; 1232774
dc.information.autorucEscuela de Medicina; Roa Strauch, Juan Carlos Enrique; 0000-0001-8313-8774; 84743
dc.information.autorucNo Informado
dc.information.autorucNo Informado; Blanco No Informado, Estela; S/I; 1232774
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final135
dc.pagina.inicio127
dc.publisherSpringer Science and Business Media B.V.
dc.relation.ispartofA Sociopolitical Turn in Science Education: Towards Post-pandemic Worlds
dc.revistaBREAST CANCER RESEARCH AND TREATMENT
dc.rightsregistro bibliográfico
dc.subjectArsenic
dc.subjectCase-control study
dc.subjectBreast cancer
dc.subjectDrinking water
dc.subjectChile
dc.subject.ddc550
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleArsenic in drinking water and breast cancer: a case-control study from a high exposure area in Northern Chile
dc.typeartículo
dc.volumen213
sipa.codpersvinculados1232774
sipa.codpersvinculados84743
sipa.codpersvinculados1232774
sipa.indexScopus
sipa.indexWOS
sipa.trazabilidadWOS-SCOPUS;2025-12-15
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