Hyperforin prevents β-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-β-deposits

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dc.contributor.authorDinamarca, M. C.
dc.contributor.authorCerpa, W.
dc.contributor.authorGarrido, J.
dc.contributor.authorHancke, J. L.
dc.contributor.authorInestrosa, N. C.
dc.date.accessioned2025-01-21T01:05:50Z
dc.date.available2025-01-21T01:05:50Z
dc.date.issued2006
dc.description.abstractThe major protein constituent of amyloid deposits in Alzheimer's disease (AD) is the amyloid beta-peptide (A beta). In the present work, we have determined the effect of hyperforin an acylphloroglucinol compound isolated from Hypericum perforatum (St John's Wort), on A beta-induced spatial memory impairments and on A beta neurotoxicity. We report here that hyperforin: ( 1) decreases amyloid deposit formation in rats injected with amyloid fibrils in the hippocampus; ( 2) decreases the neuropathological changes and behavioral impairments in a rat model of amyloidosis; ( 3) prevents A beta-induced neurotoxicity in hippocampal neurons both from amyloid fibrils and A beta oligomers, avoiding the increase in reactive oxidative species associated with amyloid toxicity. Both effects could be explained by the capacity of hyperforin to disaggregate amyloid deposits in a dose and time-dependent manner and to decrease A beta aggregation and amyloid formation. Altogether these evidences suggest that hyperforin may be useful to decrease amyloid burden and toxicity in AD patients, and may be a putative therapeutic agent to fight the disease.
dc.fuente.origenWOS
dc.identifier.doi10.1038/sj.mp.4001866
dc.identifier.eissn1476-5578
dc.identifier.issn1359-4184
dc.identifier.urihttps://doi.org/10.1038/sj.mp.4001866
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96028
dc.identifier.wosidWOS:000241578100008
dc.issue.numero11
dc.language.isoen
dc.pagina.final1048
dc.pagina.inicio1032
dc.revistaMolecular psychiatry
dc.rightsacceso restringido
dc.subjectamyloid-beta-peptide
dc.subjecthyperforin
dc.subjectneurotoxicity
dc.subjectspatial learning
dc.subjectdisaggregation
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHyperforin prevents β-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-β-deposits
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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