Challenges for gene therapy in the financial sustainability of health systems: a scoping review

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dc.article.number243
dc.catalogadorpau
dc.contributor.authorOssandon, Hugo
dc.contributor.authorArmijo, Nicolás
dc.contributor.authorVargas, Constanza
dc.contributor.authorRepetto, Gabriela M.
dc.contributor.authorEspinoza, Manuel A.
dc.date.accessioned2024-07-11T14:55:30Z
dc.date.available2024-07-11T14:55:30Z
dc.date.issued2024
dc.date.updated2024-06-30T00:03:13Z
dc.description.abstractTo review the available evidence about the strategies implemented or proposed for coverage or reimbursement for currently approved gene therapies. Methods A scoping review was conducted to analyze the evidence published during the years 2016 to 2023. The main search criteria were coverage or reimbursement of gene therapy by healthcare systems. The eligible articles were those that described or proposed a financing model used to provide coverage in the various systems around the world. Results The study identified 279 publications, and after removing duplicates and screening for eligibility, 10 were included in the study. The results show that various financing models have been proposed, including subscription-based payment models, outcome-based payment models, and amortization strategies. However, several barriers to implementing these models were identified, such as deficiencies in informatics systems for data collection, changes in laws or regulations, the lack of accessible clinical endpoints and administrative costs. Conclusion This scoping review provides an overview of financing strategies for gene therapies. Gene therapies can cure rare or previously intractable diseases, but their high cost can make access difficult. Publishing experiences with these models can help evaluate their use and gather more evidence for their effectiveness.
dc.fechaingreso.objetodigital2024-07-11
dc.format.extent9 páginas
dc.fuente.origenBiomed Central
dc.identifier.citationOrphanet Journal of Rare Diseases. 2024 Jun 24;19(1):243
dc.identifier.issn1750-1172
dc.identifier.urihttps://doi.org/10.1186/s13023-024-03249-z
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87043
dc.information.autorucEscuela de Medicina; Armijo, Nicolás; S/I; 233953
dc.information.autorucEscuela de Medicina; Espinoza, Manuel A.; 0000-0001-9564-9512; 10720
dc.language.isoen
dc.nota.accesocontenido completo
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.rights.licenseCC BY 4.0 ATTRIBUTION 4.0 INTERNATIONAL
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleChallenges for gene therapy in the financial sustainability of health systems: a scoping review
dc.typeartículo
sipa.codpersvinculados233953
sipa.codpersvinculados10720
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