Covid-19 in hospitalized kidney transplant recipients: analysis of the multicenter registry during the first wave of the pandemic in Chile

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dc.contributor.authorPefaur, Jacqueline
dc.contributor.authorToro, Luis
dc.contributor.authorBadilla, Ximena
dc.contributor.authorArdiles, Leopoldo
dc.contributor.authorBoltansky, Andres
dc.contributor.authorRosatti, Pia
dc.contributor.authorTapia, Beatriz
dc.contributor.authorRocca, Ximena
dc.contributor.authorMur, Paola
dc.contributor.authorFernandez, Alicia
dc.contributor.authorCastillo, Alvaro
dc.contributor.authorDiaz, Carolina
dc.contributor.authorElgueta, Leticia
dc.contributor.authorGarcia, Francisco
dc.contributor.authorMueller, Hans
dc.contributor.authorMansilla, Rodrigo
dc.contributor.authorMunoz, Carolina
dc.contributor.authorSalvatici, Marcelo
dc.contributor.authorSelame, Maria Esperanza
dc.contributor.authorValenzuela, Marcela
dc.contributor.authorZamora, Daniela
dc.contributor.authorEnciso, Giovanni
dc.contributor.authorPanace, Rita
dc.contributor.authorCabrera, Sebastian
dc.contributor.authorOrtiz, Ana Mireya
dc.contributor.authorMardones, Sandra
dc.contributor.authorOshiro, Carolina
dc.contributor.authorSanchez, Juan Eduardo
dc.contributor.authorLorca, Eduardo
dc.contributor.authorTorres, Ruben
dc.date.accessioned2025-01-20T16:15:24Z
dc.date.available2025-01-20T16:15:24Z
dc.date.issued2024
dc.description.abstractIntroduction: The severity of COVID-19 infection in kidney transplant patients has been well -documented. Objectives : This study aims to determine the epidemiological and clinical data and identify predictors of poor prognosis during the epidemic's early stages. Material and methods : This is a national semi -prospective, multicenter study of subjects with functioning grafts who were infected during the first wave of the pandemic in Chile between March 1 and September 31, 2020. Results : during this period, we recorded the hospitalization of 97 adult patients throughout the entire national territory. The average age was 52.5 years, 62% men, 45% hypertensive, 11% coronary, 10% diabetic, and 5% with chronic obstructive pulmonary disease, with an average post -transplant follow-up of 7.2 years and an average previous renal function of 47.7ml/min/1.7m2 (CKD-EPI formula). Between the onset of symptoms and diagnosis, there was an average period of 4.8 days, with a predominance of cough (44%), dyspnea (42%), and fever (42%). 34% developed acute kidney injury, and 36% of them required dialysis support. The lethality was 30%, prevailing in those with multiple organ failure (80%) and those who required invasive mechanical ventilation (52%). In the multivariate analysis, the best predictors of mortality were older age (OR: 2.92) and living in a low-income commune (OR: 2.35). Conclusions : This national project of the Chilean Society of Nephrology provided valuable information for monitoring the epidemiological evolution of the pandemic. It also helped to propose priority vaccination strategies, adjust immunosuppressive therapy, and design logistical aspects to reduce the risks for transplant patients.
dc.fuente.origenWOS
dc.identifier.eissn2346-8548
dc.identifier.issn0326-3428
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90493
dc.identifier.wosidWOS:001250222900004
dc.issue.numero2
dc.language.isoen
dc.pagina.final98
dc.pagina.inicio91
dc.revistaRevista de nefrologia dialisis y trasplante
dc.rightsacceso restringido
dc.subjectPandemic
dc.subjectKidney Transplantation
dc.subjectCovid-19
dc.subjectMortality
dc.subjectChile
dc.subjectSyndemic
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCovid-19 in hospitalized kidney transplant recipients: analysis of the multicenter registry during the first wave of the pandemic in Chile
dc.typeartículo
dc.volumen44
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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