Experimental antihyperglycemic effect of diterpenoids of llareta <i>Azorella</i> <i>compacta</i> (Umbelliferae) Phil in rats

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dc.contributor.authorFuentes, NL
dc.contributor.authorSagua, H
dc.contributor.authorMorales, G
dc.contributor.authorBorquez, J
dc.contributor.authorMartin, AS
dc.contributor.authorSoto, J
dc.contributor.authorLoyola, LA
dc.date.accessioned2025-01-21T01:06:49Z
dc.date.available2025-01-21T01:06:49Z
dc.date.issued2005
dc.description.abstractAqueous or ethanol infusions of Azorella compacta (llareta) in common with many other plants have been used as antidiabetic in the popular medicine in the altiplanic region of Chile. In order to determine if the diterpenic compounds chemically elucidated and isolated from this plant are responsible for this effect, streptozotocin diabetic rats (507 +/- 67 mg/mL glucose) were injected with two injections of diterpenic compounds mulinolic acid, azorellanol, and mulin-11,13-dien-20-oic acid at 180 mg/mL. Glycemia of animals treated with mulinolic acid and azorellanol was decreased to 243 2 and 247 14 mg/mL respectively, values very close to those reached by chlorpropamide injection used in controls. After 3 h treatment with mulin-11,13-dien-20-oic acid no effect was detected. The blood serum insulin in diabetic rats (146 +/- 58 pg/mL) was lower than in control rats. After injection of azorellanol, insulin was elevated to 247 23 pg/mL but with mulinolic acid, insulin was not changed. The antihyperglycemic effect of these compounds may explain the effectiveness of llareta in popular medicine. Because of the similarity to the hypoglycemic medication chlorpropamide, azorellanol could be acting on the P cells of pancreatic islets, while mulinollic acid may act upon glucose utilization or production in the liver. Copyright (c) 2005 John Wiley & Sons, Ltd.
dc.fuente.origenWOS
dc.identifier.doi10.1002/ptr.1740
dc.identifier.eissn1099-1573
dc.identifier.issn0951-418X
dc.identifier.urihttps://doi.org/10.1002/ptr.1740
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96227
dc.identifier.wosidWOS:000232527600012
dc.issue.numero8
dc.language.isoen
dc.pagina.final716
dc.pagina.inicio713
dc.revistaPhytotherapy research
dc.rightsacceso restringido
dc.subjectAzorella compacta
dc.subjectllareta
dc.subjectditerpenoids
dc.subjectantihyperglycemic
dc.subjectinsulin
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExperimental antihyperglycemic effect of diterpenoids of llareta <i>Azorella</i> <i>compacta</i> (Umbelliferae) Phil in rats
dc.typeartículo
dc.volumen19
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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