ANTIOXIDANT PROPERTIES OF THE ALKALOID BOLDINE IN SYSTEMS UNDERGOING LIPID-PEROXIDATION AND ENZYME INACTIVATION

Simple item page
dc.contributor.authorSPEISKY, H
dc.contributor.authorCASSELS, BK
dc.contributor.authorLISSI, EA
dc.contributor.authorVIDELA, LA
dc.date.accessioned2025-01-23T19:22:39Z
dc.date.available2025-01-23T19:22:39Z
dc.date.issued1991
dc.description.abstractBoldine, in low micromolar concentrations, was able to prevent brain homogenate auto-oxidation, the 2,2'-azobis(2-amidinopropane)(AAP)-induced lipid peroxidation of red cell plasma membranes, and the AAP-induced inactivation of lysozyme. These results are indicative of a high reactivity of boldine towards free radicals. The analysis of the boldine effect as a function of incubation times suggests that a metabolite resulting from the interaction of boldine with free radicals also exhibits antioxidant activity, being more efficient than boldine in brain homogenate auto-oxidation and less efficient in lysozyme protection experiments. This behavior may be accounted for in terms of the relative location of the scavengers needed to afford maximal protection.
dc.fuente.origenWOS
dc.identifier.eissn1873-2968
dc.identifier.issn0006-2952
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99073
dc.identifier.wosidWOS:A1991FN89500005
dc.issue.numero11
dc.language.isoen
dc.pagina.final1581
dc.pagina.inicio1575
dc.revistaBiochemical pharmacology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleANTIOXIDANT PROPERTIES OF THE ALKALOID BOLDINE IN SYSTEMS UNDERGOING LIPID-PEROXIDATION AND ENZYME INACTIVATION
dc.typeartículo
dc.volumen41
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas