Preserved Omicron Spike specific antibody binding and Fc-recognition across COVID-19 vaccine platforms

Simple item page
dc.catalogadorpau
dc.contributor.authorBartsch, Y.
dc.contributor.authorTong, X.
dc.contributor.authorKang, J.
dc.contributor.authorAlter, G.
dc.contributor.authorAvendaño, María José
dc.contributor.authorSerrano, Eileen F.
dc.contributor.authorGarcía-Salum, Tamara
dc.contributor.authorPardo-Roa, Catalina
dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorMedina, Rafael A.
dc.date.accessioned2025-07-02T19:16:37Z
dc.date.available2025-07-02T19:16:37Z
dc.date.issued2021
dc.description.abstractDespite the dramatic spread of Omicron globally, even among highly vaccinated populations, death rates have not increased concomitantly. These data argue that alternative immune mechanisms, beyond neutralization, may continue to confer protection against severe disease. Beyond their ability to bind and block infection, antibodies contribute to control and clearance of multiple infections via their ability to direct antiviral immunity via Fc-effector mechanisms. Thus, here we probed the ability of vaccine induced antibodies, across three COVID-19 vaccines, to drive Fc-effector activity against Omicron. Despite the significant loss of IgM, IgA and IgG binding to the Omicron Receptor Binding Domain (RBD) across BNT162b2, mRNA-1273, and CoronaVac vaccines, stable isotype binding was observed across all of these vaccines to the Omicron Spike. Compromised RBD binding IgG was accompanied by a significant loss of cross RBD-specific antibody Fcγ-receptor binding by the CoronaVac vaccine, but preservation of RBD-specific FcγR2a and Fcγ3a binding across the mRNA vaccines. Conversely, Spike-specific antibodies exhibited persistent binding to Fcγ-receptors, across all three vaccines, albeit higher binding was observed with the mRNA vaccines, marked by a selective preservation of FcγR2a and Fcγ3a binding antibodies. Thus, despite the significant to near complete loss of Omicron neutralization across several vaccine platforms against Omicron, vaccine induced Spike-specific antibodies continue to recognize the virus and recruit Fc-receptors pointing to a persistent capacity for extra-neutralizing antibodies to contribute Omicron disease attenuation.
dc.fechaingreso.objetodigital2025-07-02
dc.format.extent15 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1101/2021.12.24.21268378
dc.identifier.urihttps://doi.org/10.1101/2021.12.24.21268378
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-85122915700&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104830
dc.information.autorucFacultad de Ciencias Biológicas; Pardo Roa, Catalina; 0000-0002-5409-225X; 225251
dc.information.autorucFacultad de Ciencias Biológicas; Avendaño, María José; S/I; 1086420
dc.information.autorucFacultad de Ciencias Biológicas; Serrano, Eileen F.; S/I; 1086419
dc.information.autorucEscuela de Medicina; Riquelme, Arnoldo; 0000-0002-8259-8960; 3538
dc.information.autorucEscuela de Medicina; Medina, Rafael A.; 0000-0002-5013-6884; 1000649
dc.language.isoen
dc.nota.accesocontenido completo
dc.rightsacceso abierto
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePreserved Omicron Spike specific antibody binding and Fc-recognition across COVID-19 vaccine platforms
dc.typepreprint
sipa.codpersvinculados225251
sipa.codpersvinculados1086420
sipa.codpersvinculados1086419
sipa.codpersvinculados3538
sipa.codpersvinculados1000649
sipa.trazabilidadORCID;2025-06-23
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
preserved omicron spike specific antibody binding and FC recognition across COVID 19 vaccine platforms.pdf
Size:
499.53 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas