The Emerging Role of PIWI-Interacting RNAs (piRNAs) in Gastrointestinal Cancers: An Updated Perspective

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dc.article.number102546
dc.article.number102546
dc.contributor.authorRiquelme, Ismael
dc.contributor.authorPerez Moreno, Pablo
dc.contributor.authorLetelier, Pablo
dc.contributor.authorBrebi, Priscilla
dc.contributor.authorRoa, Juan Carlos
dc.date.accessioned2025-05-01T10:32:10Z
dc.date.available2025-05-01T10:32:10Z
dc.date.issued2022
dc.description.abstractSimple Summary Gastrointestinal (GI) cancers are high mortality malignancies due to late diagnosis, the presence of metastasis and drug resistance development. Novel and more reliable biomarkers and therapeutic targets are still needed for these diseases. PIWI-interacting RNAs (piRNAs) are small transcripts that are involve in gastrointestinal carcinogenesis and have been proposed as promising diagnostic or prognostic biomarkers and as potential therapeutic targets in these malignancies. This review describes important topics about piRNAs including their molecular characteristics, biosynthesis processes, gene expression silencing mechanisms, and the manner in which these transcripts have been studied in samples and cell lines of GI cancers. In addition, this article discusses the potential clinical usefulness of piRNAs as biomarkers and therapeutic targets in GI cancers. Gastrointestinal (GI) cancers produce ~3.4 million related deaths worldwide, comprising 35% of all cancer-related deaths. The high mortality among GI cancers is due to late diagnosis, the presence of metastasis and drug resistance development. Additionally, current clinical markers do not adequately guide patient management, thereby new and more reliable biomarkers and therapeutic targets are still needed for these diseases. RNA-seq technology has allowed the discovery of new types of RNA transcripts including PIWI-interacting RNAs (piRNAs), which have particular characteristics that enable these molecules to act via diverse molecular mechanisms for regulating gene expression. Cumulative evidence has described the potential role of piRNAs in the development of several tumor types as a likely explanation for certain genomic abnormalities and signaling pathways' deregulations observed in cancer. In addition, these piRNAs might be also proposed as promising diagnostic or prognostic biomarkers or as potential therapeutic targets in malignancies. This review describes important topics about piRNAs including their molecular characteristics, biosynthesis processes, gene expression silencing mechanisms, and the manner in which these transcripts have been studied in samples and cell lines of GI cancers to elucidate their implications in these diseases. Moreover, this article discusses the potential clinical usefulness of piRNAs as biomarkers and therapeutic targets in GI cancers.
dc.description.funderNational Fund for Scientific and Technological Development (FONDECYT)
dc.description.funderResearch Direction from Universidad Autonoma de Chile (DIUA)
dc.description.funderVicerrectoria Investigacion de Universidad Catolica de Temuco
dc.description.funderResearch Direction from Universidad de La Frontera (DIUFRO)
dc.description.funderFONDEF Idea
dc.description.funderMillennium Institute on Immunology and Immunotherapy (IMII)
dc.description.funderEuropean Research Council (ERC) under the European Union
dc.format.extent27 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3390/cancers14010202
dc.identifier.eisbn978-84-9880-797-4
dc.identifier.eissn2072-6694
dc.identifier.isbn978-3-031-28205-8
dc.identifier.issn0004-0614
dc.identifier.pubmedidMEDLINE:35008366
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:66149183263
dc.identifier.urihttps://doi.org/10.3390/cancers14010202
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103834
dc.identifier.wosidWOS:000752575600001
dc.information.autorucEscuela de Medicina; Roa Strauch Juan Carlos Enrique; 0000-0001-8313-8774; 84743
dc.issue.numero1
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final55
dc.pagina.inicio49
dc.publisherPalgrave Macmillan
dc.relation.ispartofCreativity, Innovation, and Change Across Cultures
dc.revistaCANCERS
dc.rightsregistro bibliográfico
dc.subjectPIWI-interacting RNAs (piRNAs)
dc.subjectgastrointestinal cancers (GI cancers)
dc.subjectprognostic biomarkers
dc.subjectdiagnostic biomarkers
dc.subjecttherapeutic targets
dc.subjectNONCODING RNAS
dc.subjectPATHWAY
dc.subjectBIOGENESIS
dc.subjectDIAGNOSIS
dc.subjectBIOMARKER
dc.subjectPROTEINS
dc.subjectMARKERS
dc.subjectPIR-823
dc.subjectGENOME
dc.subjectEPIDEMIOLOGY
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Emerging Role of PIWI-Interacting RNAs (piRNAs) in Gastrointestinal Cancers: An Updated Perspective
dc.typeartículo
dc.volumen14
sipa.codpersvinculados84743
sipa.indexWOS
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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