Changes in macrophage immunometabolism as a marker of skeletal muscle dysfunction across the lifespan

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dc.contributor.authorLiu, Norika
dc.contributor.authorButcher, Joshua T.
dc.contributor.authorNakano, Atsushi
dc.contributor.authordel Campo, Andrea
dc.date.accessioned2025-01-20T20:09:06Z
dc.date.available2025-01-20T20:09:06Z
dc.date.issued2023
dc.description.abstractOne of the most pronounced changes in the elderly is loss of strength and mobility due to the decline of skeletal muscle function, resulting in a multifactorial condition termed sarcopenia. Although significant clinical changes begin to manifest at advanced ages, recent studies have shown that changes at the cellular and molecular level precede the symptomatology of sarcopenia. By utilizing a single-cell transcriptomic atlas of mouse skeletal muscle across the lifespan, we identified a clear sign of immune senescence that presents during middle age. More importantly, the change in macrophage phenotype in middle age may explain the changes in extracellular matrix composition, especially collagen synthesis, that contributes to fibrosis and overall muscle weakness with advanced age. Our results show a novel paradigm whereby skeletal muscle dysfunction is driven by alterations in tissue-resident macrophages before the appearance of clinical symptoms in middle-aged mice, providing a new therapeutic approach via regulation of immunometabolism.
dc.fuente.origenWOS
dc.identifier.issn1945-4589
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91968
dc.identifier.wosidWOS:001009944300010
dc.issue.numero10
dc.language.isoen
dc.pagina.final4050
dc.pagina.inicio4035
dc.revistaAging-us
dc.rightsacceso restringido
dc.subjectimmunometabolism
dc.subjectmacrophage
dc.subjectsarcopenia
dc.subjectaging
dc.subjectscRNA-seq
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleChanges in macrophage immunometabolism as a marker of skeletal muscle dysfunction across the lifespan
dc.typeartículo
dc.volumen15
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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