Vitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos

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dc.contributor.authorQuiroz, Alonso
dc.contributor.authorBelledonne, Gabriela
dc.contributor.authorSaavedra, Fujiko
dc.contributor.authorGonzalez, Javier
dc.contributor.authorBusso, Dolores
dc.date.accessioned2025-01-20T16:05:41Z
dc.date.available2025-01-20T16:05:41Z
dc.date.issued2024
dc.description.abstractIntroduction Genetic and environmental factors influence the risk of neural tube defects (NTD), congenital malformations characterized by abnormal brain and spine formation. Mouse embryos deficient in Scavenger Receptor Class B Type 1 (SR-B1), which is involved in the bidirectional transfer of lipids between lipoproteins and cells, exhibit a high prevalence of exencephaly, preventable by maternal vitamin E supplementation. SR-B1 knock-out (KO) embryos are severely deficient in vitamin E and show elevated reactive oxygen species levels during neurulation.Methods We fed SR-B1 heterozygous female mice a high-fat/high-sugar (HFHS) diet and evaluated the vitamin E and oxidative status in dams and embryos from heterozygous intercrosses. We also determined the incidence of NTD.Results and discussion HFHS-fed SR-B1 HET females exhibited altered glucose metabolism and excess circulating lipids, along with a higher incidence of embryos with developmental delay and NTD. Vitamin E supplementation partially mitigated HFHS-induced maternal metabolic abnormalities and completely prevented embryonic malformations, likely through indirect mechanisms involving the reduction of oxidative stress and improved lipid handling by the parietal yolk sac.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fcell.2024.1460697
dc.identifier.issn2296-634X
dc.identifier.urihttps://doi.org/10.3389/fcell.2024.1460697
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89913
dc.identifier.wosidWOS:001338393700001
dc.language.isoen
dc.revistaFrontiers in cell and developmental biology
dc.rightsacceso restringido
dc.subjectembryo development
dc.subjectneural tube defects
dc.subjectmalnutrition by excess
dc.subjectvitamin E
dc.subjectSR-B1 deficiency
dc.titleVitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos
dc.typeartículo
dc.volumen12
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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