Trichoscopic, oral, and periungual fold findings as activity and damage markers in dermatomyositis patients and their correlation with myositis antibodies

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dc.catalogadoryvc
dc.contributor.authorSalgueiro, Catalina
dc.contributor.authorPoblete, María José
dc.contributor.authorRobles-Silva, Christian
dc.contributor.authorAbarzúa Araya, Álvaro Rodrigo
dc.contributor.authorVera-Kellet, Cristián
dc.date.accessioned2024-01-19T14:06:47Z
dc.date.available2024-01-19T14:06:47Z
dc.date.issued2023
dc.description.abstractThere is little clarity about the clinical manifestations of dermatomyositis (DM) in the periungual folds, scalp, and oral cavity and their association with disease activity and damage. The objective of this study was to compare the prevalence of trichoscopic, oral, and periungual changes between DM and healthy patients and assess their possible association with disease activity and damage. We conducted an observational, transversal, and analytical study between 2020 and 2021. Forty DM patients were matched by sex and age with 40 healthy individuals. On the same day, all patients had a clinical evaluation of the hands, periungual folds, scalp, and oral cavity. Photographs of these areas and peripheral venous blood tests, including myositis-associated (MAAs) and myositis-specifc antibodies (MSAs), were taken. Two dermatologists blinded to their diagnosis, damage, and activity levels registered the lesions. The disease activity and damage were evaluated using the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI). The presence of mechanic’s hands, Gottron’s sign, and Gottron’s papules in hands; capillary dilation, capillary tortuosity, cuticular hemorrhage, avascular areas, and cuticular hyperkeratosis in periungual folds; thick tortuous capillaries in scalp; gingival telangiectasias in the oral cavity; and positive MSAs associated with severe cutaneous involvement in DM patients (Anti-TIF1g, Anti-MDA5, Anti-SAE1/2) were associated with a higher CDASI activity score. The presence of MSAs associated with intense muscle involvement in DM patients (Anti-Mi2a, Anti-Mi2b, Anti-NPX2, and Anti-SAE1/2) was related to a lower CDASI activity score. Gottron’s sign and Gottron’s papules in hands; capillary dilation, capillary tortuosity, cuticular hemorrhage, avascular areas, and cuticular hyperkeratosis in periungual folds; basal erythema in scalp; and gingival telangiectasias in the oral cavity were associated with a higher CDASI damage score. There are trichoscopic, oral and periungual fold fndings and some myositis-specifc antibodies that correlate with disease activity and damage in DM patients.
dc.fechaingreso.objetodigital2024-02-28
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1007/s00403-023-02554-0
dc.identifier.urihttps://doi.org/10.1007/s00403-023-02554-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80652
dc.identifier.wosidWOS:000931745100003
dc.information.autorucEscuela de medicina ; Abarzúa Araya, Álvaro Rodrigo ; 0000-0002-7036-0699 ; 85465
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1613
dc.pagina.inicio1603
dc.revistaArchives of Dermatological Research
dc.rightsacceso restringido
dc.subjectDermatomyositis
dc.subjectDermoscopy
dc.subjectNail-fold
dc.subjectOral manifestations
dc.subjectAutoantibodies
dc.subjectDisease activity
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTrichoscopic, oral, and periungual fold findings as activity and damage markers in dermatomyositis patients and their correlation with myositis antibodies
dc.typeartículo
dc.volumen315
sipa.codpersvinculados85465
sipa.trazabilidadORCID;2024-01-08
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