Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome Insights from the LUNG SAFE Study

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dc.contributor.authorTai Pham
dc.contributor.authorNeto, Ary Serpa
dc.contributor.authorPelosi, Paolo
dc.contributor.authorLaffey, John Gerard
dc.contributor.authorDe Haro, Candelaria
dc.contributor.authorAngel Lorente, Jose
dc.contributor.authorBellani, Giacomo
dc.contributor.authorFan, Eddy
dc.contributor.authorBrochard, Laurent Jean
dc.contributor.authorPesenti, Antonio
dc.contributor.authorSchultz, Marcus Josephus
dc.contributor.authorArtigas, Antonio
dc.contributor.authorEsteban, Andres
dc.contributor.authorGattinoni, Luciano
dc.contributor.authorvan Haren, Frank
dc.contributor.authorLarsson, Anders
dc.contributor.authorMcAuley, Daniel F.
dc.contributor.authorRanieri, Marco
dc.contributor.authorRubenfeld, Gordon
dc.contributor.authorThompson, B. Taylor
dc.contributor.authorWrigge, Hermann
dc.contributor.authorSlutsky, Arthur S.
dc.contributor.authorRios, Fernando
dc.contributor.authorSottiaux, Thierry
dc.contributor.authorDepuydt, Pieter
dc.contributor.authorLora, Fredy S.
dc.contributor.authorAzevedo, Luciano Cesar
dc.contributor.authorBugedo, Guillermo
dc.contributor.authorQiu, Haibo
dc.contributor.authorGonzalez, Marcos
dc.contributor.authorSilesky, Juan
dc.contributor.authorCerny, Vladimir
dc.contributor.authorNielsen, Jonas
dc.contributor.authorJibaja, Manuel
dc.contributor.authorMatamis, Dimitrios
dc.contributor.authorLuis Ranero, Jorge
dc.contributor.authorAmin, Pravin
dc.contributor.authorHashemian, S. M.
dc.contributor.authorClarkson, Kevin
dc.contributor.authorKurahashi, Kiyoyasu
dc.contributor.authorVillagomez, Asisclo
dc.contributor.authorZeggwagh, Amine Ali
dc.contributor.authorHeunks, Leo M.
dc.contributor.authorLaake, Jon Henrik
dc.contributor.authorEmmanuel Palo, Jose
dc.contributor.authorFernandes, Antero do Vale
dc.contributor.authorSandesc, Dorel
dc.contributor.authorArabi, Yaasen
dc.contributor.authorBumbasierevic, Vesna
dc.contributor.authorNin, Nicolas
dc.contributor.authorPiquilloud, Lise
dc.contributor.authorAbroug, Fekri
dc.contributor.authorMcNamee, Lia
dc.contributor.authorHurtado, Javier
dc.contributor.authorBajwa, Ed
dc.contributor.authorDempaire, Gabriel
dc.contributor.authorSula, Hektor
dc.contributor.authorNunci, Lordian
dc.contributor.authorCani, Alma
dc.contributor.authorZazu, Alan
dc.contributor.authorDellera, Christian
dc.contributor.authorInsaurralde, Carolina S.
dc.contributor.authorAlejandro, Risso, V
dc.contributor.authorDaldin, Julio
dc.contributor.authorVinzio, Mauricio
dc.contributor.authorFernandez, Ruben O.
dc.contributor.authorCardonnet, Luis P.
dc.contributor.authorBettini, Lisandro R.
dc.contributor.authorCarboni Bisso, Mariano
dc.contributor.authorOsman, Emilio M.
dc.contributor.authorSetten, Mariano G.
dc.contributor.authorLovazzano, Pablo
dc.contributor.authorAlvarez, Javier
dc.contributor.authorVillar, Veronica
dc.contributor.authorPozo, Norberto C.
dc.contributor.authorGrubissich, Nicolas
dc.contributor.authorPlotnikow, Gustavo A.
dc.contributor.authorVasquez, Daniela N.
dc.contributor.authorIlutovich, Santiago
dc.contributor.authorTiribelli, Norberto
dc.contributor.authorChena, Ariel
dc.contributor.authorPellegrini, Carlos A.
dc.contributor.authorSaenz, Maria G.
dc.contributor.authorEstenssoro, Elisa
dc.contributor.authorBrizuela, Matias
dc.contributor.authorGianinetto, Hernan
dc.contributor.authorGomez, Pablo E.
dc.contributor.authorCerrato, Valeria, I
dc.contributor.authorBezzi, Marco G.
dc.contributor.authorBorello, Silvina A.
dc.contributor.authorLoiacono, Flavia A.
dc.contributor.authorFernandez, Adriana M.
dc.contributor.authorKnowles, Serena
dc.contributor.authorReynolds, Claire
dc.contributor.authorInskip, Deborah M.
dc.contributor.authorMiller, Jennene J.
dc.contributor.authorKong, Jing
dc.contributor.authorWhitehead, Christina
dc.contributor.authorBihari, Shailesh
dc.contributor.authorSeven, Aylin
dc.contributor.authorKrstevski, Amanda
dc.contributor.authorRodgers, Helen J.
dc.contributor.authorMillar, Rebecca T.
dc.contributor.authorMckenna, Toni E.
dc.contributor.authorBailey, Irene M.
dc.contributor.authorHanlon, Gabrielle C.
dc.contributor.authorAneman, Anders
dc.contributor.authorLynch, Joan M.
dc.contributor.authorAzad, Raman
dc.contributor.authorNeal, John
dc.contributor.authorWoods, Paul W.
dc.contributor.authorRoberts, Brigit L.
dc.contributor.authorKol, Mark R.
dc.contributor.authorWong, Helen S.
dc.contributor.authorRiss, Katharina C.
dc.contributor.authorStaudinger, Thomas
dc.contributor.authorWittebole, Xavier
dc.contributor.authorBerghe, Caroline
dc.contributor.authorBulpa, Pierre A.
dc.contributor.authorDive, Alain M.
dc.contributor.authorVerstraete, Rik
dc.contributor.authorLebbinck, Herve
dc.contributor.authorVermassen, Joris
dc.contributor.authorMeersseman, Philippe
dc.contributor.authorCeunen, Helga
dc.contributor.authorRosa, Jonas, I
dc.contributor.authorBeraldo, Daniel O.
dc.contributor.authorPiras, Claudio
dc.contributor.authorRampinelli, Adenilton M.
dc.contributor.authorNassar Jr, Antonio P.
dc.contributor.authorMataloun, Sergio
dc.contributor.authorMoock, Marcelo
dc.contributor.authorThompson, Marlus M.
dc.contributor.authorGoncalves, Claudio H.
dc.contributor.authorAntonio, Ana Carolina P.
dc.contributor.authorAscoli, Aline
dc.contributor.authorBiondi, Rodrigo S.
dc.contributor.authorFontenele, Danielle C.
dc.contributor.authorNobrega, Danielle
dc.contributor.authorSales, Vanessa M.
dc.contributor.authorAbul Wahab, Ahmad Yazid Bin H. J.
dc.contributor.authorIsmail, Maizatul
dc.contributor.authorShindhe, Suresh
dc.contributor.authorBeloncle, Francois
dc.contributor.authorDavies, Kyle G.
dc.contributor.authorCirone, Rob
dc.contributor.authorManoharan, Venika
dc.contributor.authorIsmail, Mehvish
dc.contributor.authorGoligher, Ewan C.
dc.contributor.authorJassal, Mandeep
dc.contributor.authorNishikawa, Erin
dc.contributor.authorJaveed, Areej
dc.contributor.authorCurley, Gerard
dc.contributor.authorRittayamai, Nuttapol
dc.contributor.authorParotto, Matteo
dc.contributor.authorFerguson, Niall D.
dc.contributor.authorMehta, Sangeeta
dc.contributor.authorKnoll, Jenny
dc.contributor.authorPronovost, Antoine
dc.contributor.authorCanestrini, Sergio
dc.contributor.authorBruhn, Alejandro R.
dc.contributor.authorGarcia, Patricio H.
dc.contributor.authorAliaga, Felipe A.
dc.contributor.authorFarias, Pamela A.
dc.contributor.authorYumha, Jacob S.
dc.contributor.authorOrtiz, Claudia A.
dc.contributor.authorSalas, Javier E.
dc.contributor.authorSaez, Alejandro A.
dc.contributor.authorVega, Luis D.
dc.contributor.authorLabarca, Eduardo F.
dc.contributor.authorMartinez, Felipe T.
dc.contributor.authorCarreno, Nicolas G.
dc.contributor.authorLora, Pilar
dc.contributor.authorLiu, Haitao
dc.contributor.authorLiu, Ling
dc.contributor.authorTang, Rui
dc.contributor.authorLuo, Xiaoming
dc.contributor.authorAn, Youzhong
dc.contributor.authorZhao, Huiying
dc.contributor.authorGao, Yan
dc.contributor.authorZhai, Zhe
dc.contributor.authorYe, Zheng L.
dc.contributor.authorWang, Wei
dc.contributor.authorLi, Wenwen
dc.contributor.authorLi, Qingdong
dc.contributor.authorZheng, Ruiqiang
dc.contributor.authorYu, Wenkui
dc.contributor.authorShen, Juanhong
dc.contributor.authorLi, Xinyu
dc.contributor.authorYu, Tao
dc.contributor.authorLu, Weihua
dc.contributor.authorWu, Ya Q.
dc.contributor.authorHuang, Xiao B.
dc.contributor.authorHe, Zhenyang
dc.contributor.authorLu, Yuanhua
dc.contributor.authorHan, Hui
dc.contributor.authorZhang, Fan
dc.contributor.authorSun, Renhua
dc.contributor.authorWang, Hua X.
dc.contributor.authorQin, Shu H.
dc.contributor.authorZhu, Bao H.
dc.contributor.authorZhao, Jun
dc.contributor.authorLiu, Jian
dc.contributor.authorLi, Bin
dc.contributor.authorLiu, Jing L.
dc.contributor.authorZhou, Fa C.
dc.contributor.authorLi, Qiong J.
dc.contributor.authorZhang, Xing Y.
dc.contributor.authorZhou Li-Xin
dc.contributor.authorQiang Xin-Hua
dc.contributor.authorJiang, Liangyan
dc.contributor.authorGao, Yuan N.
dc.contributor.authorZhao, Xian Y.
dc.contributor.authorLi, Yuan Y.
dc.contributor.authorLi, Xiao L.
dc.contributor.authorWang, Chunting
dc.contributor.authorYao, Qingchun
dc.contributor.authorYu, Rongguo
dc.contributor.authorChen, Kai
dc.contributor.authorShao, Huanzhang
dc.contributor.authorQin, Bingyu
dc.contributor.authorHuang, Qing Q.
dc.contributor.authorZhu, Wei H.
dc.contributor.authorHang, Ai Y.
dc.contributor.authorHua, Ma X.
dc.contributor.authorLi, Yimin
dc.contributor.authorXu, Yonghao
dc.contributor.authorDi, Yu D.
dc.contributor.authorLing, Long L.
dc.contributor.authorQin, Tie H.
dc.contributor.authorWang, Shou H.
dc.contributor.authorQin, Junping
dc.contributor.authorHan, Yi
dc.contributor.authorZhou, Suming
dc.contributor.authorVargas, Monica P.
dc.contributor.authorSilesky Jimenez, Juan, I
dc.contributor.authorGonzalez Rojas, Manuel A.
dc.contributor.authorSolis-Quesada, Jaime E.
dc.contributor.authorRamirez-Alfaro, Christian M.
dc.contributor.authorMaca, Jan
dc.contributor.authorSklienka, Peter
dc.contributor.authorGjedsted, Jakob
dc.contributor.authorChristiansen, Aage
dc.contributor.authorVillamagua, Boris G.
dc.contributor.authorLlano, Miguel
dc.contributor.authorBurtin, Philippe
dc.contributor.authorBuzancais, Gautier
dc.contributor.authorBeuret, Pascal
dc.contributor.authorPelletier, Nicolas
dc.contributor.authorMortaza, Satar
dc.contributor.authorMercat, Alain
dc.contributor.authorChelly, Jonathan
dc.contributor.authorJochmans, Sebastien
dc.contributor.authorTerzi, Nicolas
dc.contributor.authorDaubin, Cedric
dc.contributor.authorCarteaux, Guillaume
dc.contributor.authorde Prost, Nicolas
dc.contributor.authorChiche, Jean-Daniel
dc.contributor.authorDaviaud, Fabrice
dc.contributor.authorFartoukh, Muriel
dc.contributor.authorBarberet, Guillaume
dc.contributor.authorBiehler, Jerome
dc.contributor.authorDellamonica, Jean
dc.contributor.authorDoyen, Denis
dc.contributor.authorArnal, Jean-Michel
dc.contributor.authorBriquet, Anais
dc.contributor.authorHraiech, Sami
dc.contributor.authorPapazian, Laurent
dc.contributor.authorFollin, Arnaud
dc.contributor.authorRoux, Damien
dc.contributor.authorMessika, Jonathan
dc.contributor.authorKalaitzis, Evangelos
dc.contributor.authorDangers, Laurence
dc.contributor.authorCombes, Alain
dc.contributor.authorAu, Siu-Ming
dc.contributor.authorBeduneau, Gaetan
dc.contributor.authorCarpentier, Dorothee
dc.contributor.authorZogheib, Elie H.
dc.contributor.authorDupont, Herve
dc.contributor.authorRicome, Sylvie
dc.contributor.authorSantoli, Francesco L.
dc.contributor.authorBesset, Sebastien L.
dc.contributor.authorMichel, Philippe
dc.contributor.authorGelee, Bruno
dc.contributor.authorDanin, Pierre-Eric
dc.contributor.authorGoubaux, Bernard
dc.contributor.authorCrova, Philippe J.
dc.contributor.authorPhan, Nga T.
dc.contributor.authorBerkelmans, Frantz
dc.contributor.authorBadie, Julio C.
dc.contributor.authorTapponnier, Romain
dc.contributor.authorGally, Josette
dc.contributor.authorKhebbeb, Samy
dc.contributor.authorHerbrecht, Jean-Etienne
dc.contributor.authorSchneider, Francis
dc.contributor.authorDeclercq, Pierre-Louis M.
dc.contributor.authorRigaud, Jean-Philippe
dc.contributor.authorDuranteau, Jacques
dc.contributor.authorHarrois, Anatole
dc.contributor.authorChabanne, Russell
dc.contributor.authorMarin, Julien
dc.contributor.authorBigot, Charlene
dc.contributor.authorThibault, Sandrine
dc.contributor.authorGhazi, Mohammed
dc.contributor.authorBoukhazna, Messabi
dc.contributor.authorZein, Salem Ould
dc.contributor.authorRichecoeur, Jack R.
dc.contributor.authorCombaux, Daniele M.
dc.contributor.authorGrelon, Fabien
dc.contributor.authorLe Moal, Charlene
dc.contributor.authorSauvadet, Elise P.
dc.contributor.authorRobine, Adrien
dc.contributor.authorLemiale, Virginie
dc.contributor.authorReuter, Danielle
dc.contributor.authorDres, Martin
dc.contributor.authorDemoule, Alexandre
dc.contributor.authorGoldgran-Toledano, Dany
dc.contributor.authorBaboi, Loredana
dc.contributor.authorGuerin, Claude
dc.contributor.authorLohner, Ralph
dc.contributor.authorKrassler, Jens
dc.contributor.authorSchaefer, Susanne
dc.contributor.authorZacharowski, Kai D.
dc.contributor.authorMeybohm, Patrick
dc.contributor.authorReske, Andreas W.
dc.contributor.authorSimon, Philipp
dc.contributor.authorHopf, Hans-Bernd F.
dc.contributor.authorSchuetz, Michael
dc.contributor.authorBaltus, Thomas
dc.contributor.authorPapanikolaou, Metaxia N.
dc.contributor.authorPapavasilopoulou, Theonymfi G.
dc.contributor.authorZacharas, Giannis A.
dc.contributor.authorOurailogloy, Vasilis
dc.contributor.authorMouloudi, Eleni K.
dc.contributor.authorMassa, Eleni, V
dc.contributor.authorNagy, Eva O.
dc.contributor.authorStamou, Electra E.
dc.contributor.authorKiourtzieva, Ellada, V
dc.contributor.authorOikonomou, Marina A.
dc.contributor.authorAvila, Luis E.
dc.contributor.authorCortez, Cesar A.
dc.contributor.authorCitalan, Johanna E.
dc.contributor.authorJog, Sameer A.
dc.contributor.authorSable, Safal D.
dc.contributor.authorShah, Bhagyesh
dc.contributor.authorGurjar, Mohan
dc.contributor.authorBaronia, Arvind K.
dc.contributor.authorMemon, Mohammedfaruk
dc.contributor.authorMuthuchellappan, Radhakrishnan
dc.contributor.authorRamesh, Venkatapura J.
dc.contributor.authorShenoy, Anitha
dc.contributor.authorUnnikrishnan, Ramesh
dc.contributor.authorDixit, Subhal B.
dc.contributor.authorRhayakar, Rachana, V
dc.contributor.authorRamakrishnan, Nagarajan
dc.contributor.authorBhardwaj, Vallish K.
dc.contributor.authorMahto, Heera L.
dc.contributor.authorSagar, Sudha, V
dc.contributor.authorPalaniswamy, Vijayanand
dc.contributor.authorGanesan, Deeban
dc.contributor.authorJamaati, Hamidreza
dc.contributor.authorHeidari, Farshad
dc.contributor.authorMeaney, Edel A.
dc.contributor.authorNichol, Alistair
dc.contributor.authorKnapman, Karl M.
dc.contributor.authorO'Croinin, Donall
dc.contributor.authorDunne, Eimhin S.
dc.contributor.authorBreen, Dorothy M.
dc.contributor.authorJaafar, Rola F.
dc.contributor.authorDwyer, Rory
dc.contributor.authorAmir, Fahd
dc.contributor.authorAjetunmobi, Olaitan O.
dc.contributor.authorO'Muircheartaigh, Aogan C.
dc.contributor.authorBlack, Colin S.
dc.contributor.authorTreanor, Nuala
dc.contributor.authorCollins, Daniel, V
dc.contributor.authorAltaf, Wahid
dc.contributor.authorZani, Gianluca
dc.contributor.authorFusari, Maurizio
dc.contributor.authorSpadaro, Savino
dc.contributor.authorVolta, Carlo A.
dc.contributor.authorGraziani, Romano
dc.contributor.authorBrunettini, Barbara
dc.contributor.authorPalmese, Salvatore
dc.contributor.authorFormenti, Paolo
dc.contributor.authorUmbrello, Michele
dc.contributor.authorLombardo, Andrea
dc.contributor.authorPecci, Elisabetta
dc.contributor.authorBotteri, Marco
dc.contributor.authorSavioli, Monica
dc.contributor.authorProtti, Alessandro
dc.contributor.authorMattei, Alessia
dc.contributor.authorSchiavoni, Lorenzo
dc.contributor.authorTinnirello, Andrea
dc.contributor.authorTodeschini, Manuel
dc.contributor.authorGiarratano, Antonino
dc.contributor.authorCortegiani, Andrea
dc.contributor.authorSher, Sara
dc.contributor.authorRossi, Anna
dc.contributor.authorAntonelli, Massimo M.
dc.contributor.authorMontini, Luca M.
dc.contributor.authorCasalena, Paolo
dc.contributor.authorScafetti, Sergio
dc.contributor.authorPanarello, Giovanna
dc.contributor.authorOcchipinti, Giovanna
dc.contributor.authorPatroniti, Nicolo
dc.contributor.authorPozzi, Matteo
dc.contributor.authorBiscione, Roberto R.
dc.contributor.authorPoli, Michela M.
dc.contributor.authorRaimondi, Ferdinando
dc.contributor.authorAlbiero, Daniela
dc.contributor.authorCrapelli, Giulia
dc.contributor.authorBeck, Eduardo
dc.contributor.authorPota, Vincenzo
dc.contributor.authorSchiavone, Vincenzo
dc.contributor.authorMolin, Alexandre
dc.contributor.authorTarantino, Fabio
dc.contributor.authorMonti, Giacomo
dc.contributor.authorFrati, Elena
dc.contributor.authorMirabella, Lucia
dc.contributor.authorCinnella, Gilda
dc.contributor.authorFossali, Tommaso
dc.contributor.authorColombo, Riccardo
dc.contributor.authorPattarino, Pierpaolo Terragni Ilaria
dc.contributor.authorMojoli, Francesco
dc.contributor.authorBraschi, Antonio
dc.contributor.authorBorotto, Erika E.
dc.contributor.authorCracchiolo, Andrea N.
dc.contributor.authorPalma, Daniela M.
dc.contributor.authorRaponi, Francesco
dc.contributor.authorFoti, Giuseppe
dc.contributor.authorVascotto, Ettore R.
dc.contributor.authorCoppadoro, Andrea
dc.contributor.authorBrazzi, Luca
dc.contributor.authorFloris, Leda
dc.contributor.authorIotti, Giorgio A.
dc.contributor.authorVenti, Aaron
dc.contributor.authorYamaguchi, Osamu
dc.contributor.authorTakagi, Shunsuke
dc.contributor.authorMaeyama, Hiroki N.
dc.contributor.authorWatanabe, Eizo
dc.contributor.authorYamaji, Yoshihiro
dc.contributor.authorShimizu, Kazuyoshi
dc.contributor.authorShiozaki, Kyoko
dc.contributor.authorFutami, Satoru
dc.contributor.authorRyosuke, Sekine
dc.contributor.authorSaito, Koji
dc.contributor.authorKameyama, Yoshinobu
dc.contributor.authorUeno, Keiko
dc.contributor.authorIzawa, Masayo
dc.contributor.authorOkuda, Nao
dc.contributor.authorSuzuki, Hiroyuki
dc.contributor.authorHarasawa, Tomofumi
dc.contributor.authorNasu, Michitaka
dc.contributor.authorTakada, Tadaaki
dc.contributor.authorIto, Fumihito
dc.contributor.authorNunomiya, Shin
dc.contributor.authorKoyama, Kansuke
dc.contributor.authorAbe, Toshikazu
dc.contributor.authorAndoh, Kohkichi
dc.contributor.authorKusumoto, Kohei
dc.contributor.authorHirata, Akira
dc.contributor.authorTakaba, Akihiro
dc.contributor.authorKimura, Hiroyasu
dc.contributor.authorMatsumoto, Shuhei
dc.contributor.authorHigashijima, Ushio
dc.contributor.authorHonda, Hiroyuki
dc.contributor.authorAoki, Nobumasa
dc.contributor.authorImai, Hiroshi
dc.contributor.authorOgino, Yasuaki
dc.contributor.authorMizuguchi, Ichiko
dc.contributor.authorIchikado, Kazuya
dc.contributor.authorNitta, Kenichi
dc.contributor.authorMochizuki, Katsunori
dc.contributor.authorHashida, Tomoaki
dc.contributor.authorTanaka, Hiroyuki
dc.contributor.authorNakamura, Tomoyuki
dc.contributor.authorNiimi, Daisuke
dc.contributor.authorUeda, Takeshi
dc.contributor.authorKashiwa, Yozo
dc.contributor.authorUchiyama, Akinori
dc.contributor.authorSabelnikovs, Olegs
dc.contributor.authorOss, Peteris
dc.contributor.authorHaddad, Youssef
dc.contributor.authorLiew, Kong Y.
dc.contributor.authorNamendys-Silva, Silvio A.
dc.contributor.authorJarquin-Badiola, Yves D.
dc.contributor.authorSanchez-Hurtado, Luis A.
dc.contributor.authorGomez-Flores, Saira S.
dc.contributor.authorMarin, Maria C.
dc.contributor.authorLemus, Jordana S.
dc.contributor.authorFierro, Jonathan M.
dc.contributor.authorRamirez Cervantes, Mavy
dc.contributor.authorFlores Mejia, Francisco Javier
dc.contributor.authorDector, Dulce
dc.contributor.authorRojas, Alejandro
dc.contributor.authorGonzalez, Daniel R.
dc.contributor.authorEstrella, Claudia R.
dc.contributor.authorSanchez-Medina, Jorge R.
dc.contributor.authorRamirez-Gutierrez, Alvaro
dc.contributor.authorGeorge, Fernando G.
dc.contributor.authorAguirre, Janet S.
dc.contributor.authorBuensuseso, Juan A.
dc.contributor.authorPoblano, Manuel
dc.contributor.authorDendane, Tarek
dc.contributor.authorBalkhi, Hicham
dc.contributor.authorElkhayari, Mina
dc.contributor.authorSamkaoui, Nacer
dc.contributor.authorEzzouine, Hanane
dc.contributor.authorBenslama, Abdellatif
dc.contributor.authorAmor, Mourad
dc.contributor.authorMaazouzi, Wajdi
dc.contributor.authorCimic, Nedim
dc.contributor.authorBeck, Oliver
dc.contributor.authorBruns, Monique M.
dc.contributor.authorSchouten, Jeroen A.
dc.contributor.authorRinia, Myra
dc.contributor.authorRaaijmakers, Monique
dc.contributor.authorVan Wezel, Hellen M.
dc.contributor.authorHeines, Serge J.
dc.contributor.authorStrauch, Ulrich
dc.contributor.authorBuise, Marc P.
dc.contributor.authorSimonis, Fabienne D.
dc.contributor.authorGoodson, Jennifer C.
dc.contributor.authorBrowne, Troy S.
dc.contributor.authorNavarra, Leanlove
dc.contributor.authorHunt, Anna
dc.contributor.authorHutchison, Robyn A.
dc.contributor.authorBailey, Mathew B.
dc.contributor.authorNewby, Lynette
dc.contributor.authorMcArthur, Colin
dc.contributor.authorKalkoff, Michael
dc.contributor.authorMcleod, Alex
dc.contributor.authorCasement, Jonathan
dc.contributor.authorHacking, Danielle J.
dc.contributor.authorAndersen, Finn H.
dc.contributor.authorDolva, Merete S.
dc.contributor.authorBarratt-Due, Andreas
dc.contributor.authorNoremark, Kim Andre L.
dc.contributor.authorSoreide, Eldar
dc.contributor.authorSjobo, Brit A.
dc.contributor.authorGuttormsen, Anne B.
dc.contributor.authorLeon Yoshido, Hector H.
dc.contributor.authorZumaran Aguilar, Ronald
dc.contributor.authorMontes Oscanoa, Fredy A.
dc.contributor.authorAlisasis, Alain U.
dc.contributor.authorRobles, Joanne B.
dc.contributor.authorPasanting-Lim, Rossini Abbie B.
dc.contributor.authorTan, Beatriz C.
dc.contributor.authorAndruszkiewicz, Pawel
dc.contributor.authorJakubowska, Karina
dc.contributor.authorCoxo, Cristina M.
dc.contributor.authorAlvarez, Antonio M.
dc.contributor.authorOliveira, Bruno S.
dc.contributor.authorMontanha, Gustavo M.
dc.contributor.authorBarros, Nelson C.
dc.contributor.authorPereira, Carlos S.
dc.contributor.authorMessias, Antonio M.
dc.contributor.authorMonteiro, Jorge M.
dc.contributor.authorAraujo, Ana M.
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dc.contributor.authorPastor Marcos, Diego
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dc.contributor.authorDiaz Abad, Ricardo
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dc.contributor.authorParrilla Toribio, Dacil
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dc.contributor.authorPenuelas, Oscar
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dc.contributor.authorChoudry, Shazia
dc.contributor.authorGueret, Renaud M.
dc.contributor.authorTulaimat, Aiman
dc.contributor.authorStigler, William
dc.contributor.authorBatra, Hitesh
dc.contributor.authorHuff, Nidhi G.
dc.contributor.authorLamb, Keith D.
dc.contributor.authorOetting, Trevor W.
dc.contributor.authorMohr, Nicholas M.
dc.contributor.authorJudy, Claine
dc.contributor.authorSaito, Shigeki
dc.contributor.authorKheir, Fayez
dc.contributor.authorSchlichting, Adam B.
dc.contributor.authorDelsing, Angela
dc.contributor.authorCrouch, Daniel R.
dc.contributor.authorElmasri, Mary
dc.contributor.authorIsmail, Dina
dc.contributor.authorDreyer, Kyle R.
dc.contributor.authorBlakeman, Thomas C.
dc.contributor.authorBaron, Rebecca M.
dc.contributor.authorGrijalba, Carolina Quintana
dc.contributor.authorHou, Peter C.
dc.contributor.authorSeethala, Raghu
dc.contributor.authorAisiku, Imo
dc.contributor.authorHenderson, Galen
dc.contributor.authorFrendl, Gyorgy
dc.contributor.authorHou, Sen-Kuang
dc.contributor.authorOwens, Robert L.
dc.contributor.authorSchomer, Ashley
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dc.contributor.authorVeljovic, Milic
dc.date.accessioned2025-01-23T21:19:10Z
dc.date.available2025-01-23T21:19:10Z
dc.date.issued2019
dc.description.abstractBackground: Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered to have low disease severity and favorable outcomes. They represent a relatively poorly characterized population that was only classified as having acute respiratory distress syndrome in the most recent definition. Our primary objective was to describe the natural course and the factors associated with worsening and mortality in this population.
dc.description.abstractMethods: This study analyzed patients from the international prospective Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) who had initial mild acute respiratory distress syndrome in the first day of inclusion. This study defined three groups based on the evolution of severity in the first week: " worsening" if moderate or severe acute respiratory distress syndrome criteria were met, " persisting" if mild acute respiratory distress syndrome criteria were the most severe category, and " improving" if patients did not fulfill acute respiratory distress syndrome criteria any more from day 2.
dc.description.abstractResults: Among 580 patients with initial mild acute respiratory distress syndrome, 18% (103 of 580) continuously improved, 36% (210 of 580) had persisting mild acute respiratory distress syndrome, and 46% (267 of 580) worsened in the first week after acute respiratory distress syndrome onset. Global in-hospital mortality was 30% (172 of 576; specifically 10% [10 of 101], 30% [63 of 210], and 37% [99 of 265] for patients with improving, persisting, and worsening acute respiratory distress syndrome, respectively), and the median (interquartile range) duration of mechanical ventilation was 7 (4, 14) days (specifically 3 [2, 5], 7 [4, 14], and 11 [6, 18] days for patients with improving, persisting, and worsening acute respiratory distress syndrome, respectively). Admissions for trauma or pneumonia, higher nonpulmonary sequential organ failure assessment score, lower partial pressure of alveolar oxygen/fraction of inspired oxygen, and higher peak inspiratory pressure were independently associated with worsening.
dc.description.abstractConclusions: Most patients with initial mild acute respiratory distress syndrome continue to fulfill acute respiratory distress syndrome criteria in the first week, and nearly half worsen in severity. Their mortality is high, particularly in patients with worsening acute respiratory distress syndrome, emphasizing the need for close attention to this patient population.
dc.description.funderEuropean Society of Intensive Care Medicine (ESICM)
dc.fuente.origenWOS
dc.identifier.doi10.1097/ALN.0000000000002508
dc.identifier.eissn1528-1175
dc.identifier.issn0003-3022
dc.identifier.urihttps://doi.org/10.1097/ALN.0000000000002508
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101176
dc.identifier.wosidWOS:000466747200013
dc.issue.numero2
dc.language.isoen
dc.pagina.final283
dc.pagina.inicio263
dc.revistaAnesthesiology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOutcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome Insights from the LUNG SAFE Study
dc.typeartículo
dc.volumen130
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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