Factors predictive of serious infections over time in systemic lupus erythematosus patients: data from a multi-ethnic, multi-national, Latin American lupus cohort

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dc.contributor.authorPimentel-Quiroz, V. R.
dc.contributor.authorUgarte-Gil, M. F.
dc.contributor.authorHarvey, G. B.
dc.contributor.authorWojdyla, D.
dc.contributor.authorPons-Estel, G. J.
dc.contributor.authorQuintana, R.
dc.contributor.authorEsposto, A.
dc.contributor.authorGarcia, M. A.
dc.contributor.authorCatoggio, L. J.
dc.contributor.authorCardiel, M. H.
dc.contributor.authorBarile, L. A.
dc.contributor.authorAmigo, M-C
dc.contributor.authorSato, E., I
dc.contributor.authorBonfa, E.
dc.contributor.authorBorba, E.
dc.contributor.authorLavras Costallat, L. T.
dc.contributor.authorNeira, O. J.
dc.contributor.authorMassardo, L.
dc.contributor.authorGuibert-Toledano, M.
dc.contributor.authorChacon-Diaz, R.
dc.contributor.authorAlarcon, G. S.
dc.contributor.authorPons-Estel, B. A.
dc.contributor.authorSoriano, Enrique R.
dc.contributor.authorCeballos Recalde, Maria Flavia
dc.contributor.authorVelozo, Edson
dc.contributor.authorManni, Jorge A.
dc.contributor.authorGrimaudo, Sebastian
dc.contributor.authorSarano, Judith
dc.contributor.authorMaldonado-Cocco, Jose A.
dc.contributor.authorArriola, Maria S.
dc.contributor.authorGomez, Graciela
dc.contributor.authorInes Marcos, Ana
dc.contributor.authorCarlos Marcos, Juan
dc.contributor.authorScherbarth, Hugo R.
dc.contributor.authorLopez, Jorge A.
dc.contributor.authorMotta, Estela L.
dc.contributor.authorDrenkard, Cristina
dc.contributor.authorGamron, Susana
dc.contributor.authorBuliubasich, Sandra
dc.contributor.authorOnetti, Laura
dc.contributor.authorCaeiro, Francisco
dc.contributor.authorAlvarellos, Alejandro
dc.contributor.authorSaurit, Veronica
dc.contributor.authorGentiletti, Silvana
dc.contributor.authorQuagliatto, Norberto
dc.contributor.authorGentiletti, Alberto A.
dc.contributor.authorMachado, Daniel
dc.contributor.authorAbdala, Marcelo
dc.contributor.authorPalatnik, Simon
dc.contributor.authorBerbotto, Guillermo A.
dc.contributor.authorBattagliotti, Carlos A.
dc.contributor.authorSouza, Alexandre Wagner S.
dc.contributor.authorBertolo, Manoel Barros
dc.contributor.authorCoimbra, Ibsen Bellini
dc.contributor.authorTavares Brenol, Joao C.
dc.contributor.authorMonticielo, Odirlei
dc.contributor.authorXavier, Ricardo
dc.contributor.authorCavalcanti, Fernando de Souza
dc.contributor.authorBranco Duarte, Angela Luzia
dc.contributor.authorLopes Marques, Claudia Diniz
dc.contributor.authorda Silva, Nilzio Antonio
dc.contributor.authorde O e Silva, Ana Carolina
dc.contributor.authorPacheco, Tatiana Ferracine
dc.contributor.authorFernando Molina-Restrepo, Jose
dc.contributor.authorMolina-Lopez, Javier
dc.contributor.authorVasquez, Gloria
dc.contributor.authorRamirez, Luis A.
dc.contributor.authorUribe, Oscar
dc.contributor.authorIglesias-Gamarra, Antonio
dc.contributor.authorIglesias-Rodriguez, Antonio
dc.contributor.authorEgea-Bermejo, Eduardo
dc.contributor.authorGuzman-Moreno, Renato A.
dc.contributor.authorRestrepo-Suarez, Jose F.
dc.contributor.authorAlberto Reyes-Llerena, Gil
dc.contributor.authorHernandez-Martinez, Alfredo
dc.contributor.authorJacobelli, Sergio
dc.contributor.authorGuzman, Leonardo R.
dc.contributor.authorGarcia-Kutzbach, Abraham
dc.contributor.authorCastellanos, Claudia
dc.contributor.authorCajas, Erwin
dc.contributor.authorPascual-Ramos, Virginia
dc.contributor.authorSilveira, Luis H.
dc.contributor.authorGarcia De La Torre, Ignacio
dc.contributor.authorOrozco-Barocio, Gerardo
dc.contributor.authorEstrada-Contreras, Magali L.
dc.contributor.authorSauza del Pozo, Maria Josefina
dc.contributor.authorAranda Baca, Laura E.
dc.contributor.authorUrenda Quezada, Adelfia
dc.contributor.authorHuerta-Yanez, Guillermo F.
dc.contributor.authorAcevedo-Vazquez, Eduardo M.
dc.contributor.authorLuis Alfaro-Lozano, Jose
dc.contributor.authorCucho-Venegas, Jorge M.
dc.contributor.authorInes Segami, Maria
dc.contributor.authorChung, Cecilia P.
dc.contributor.authorAlva-Linares, Magaly
dc.contributor.authorAbadi, Isaac
dc.contributor.authorRangel, Neriza
dc.contributor.authorAl Snih Al Snih, Soham
dc.contributor.authorEsteva-Spinetti, Maria H.
dc.contributor.authorVivas, Jorge
dc.date.accessioned2025-01-23T21:12:13Z
dc.date.available2025-01-23T21:12:13Z
dc.date.issued2019
dc.description.abstractAim The aim of this study was to identify factors predictive of serious infections over time in patients with systemic lupus erythematosus (SLE). Methods A multi-ethnic, multi-national Latin American SLE cohort was studied. Serious infection was defined as one that required hospitalization, occurred during a hospitalization or led to death. Potential predictors included were sociodemographic factors, clinical manifestations (per organ involved, lymphopenia and leukopenia, independently) and previous infections at baseline. Disease activity (SLEDAI), damage (SLICC/ACR Damage Index), non-serious infections, glucocorticoids, antimalarials (users and non-users), and immunosuppressive drugs use; the last six variables were examined as time-dependent covariates. Cox regression models were used to evaluate the predictors of serious infections using a backward elimination procedure. Univariable and multivariable analyses were performed. Results Of the 1243 patients included, 1116 (89.8%) were female. The median (interquartile range) age at diagnosis and follow-up time were 27 (20-37) years and 47.8 (17.9-68.6) months, respectively. The incidence rate of serious infections was 3.8 cases per 100 person-years. Antimalarial use (hazard ratio: 0.69; 95% confidence interval (CI): 0.48-0.99; p = 0.0440) was protective, while doses of prednisone >15 and <= 60 mg/day (hazard ratio: 4.18; 95 %CI: 1.69-10.31; p = 0.0019) and >60 mg/day (hazard ratio: 4.71; 95% CI: 1.35-16.49; p = 0.0153), use of methylprednisolone pulses (hazard ratio: 1.53; 95% CI: 1.10-2.13; p = 0.0124), increase in disease activity (hazard ratio: 1.03; 95% CI: 1.01-1.04; p = 0.0016) and damage accrual (hazard ratio: 1.22; 95% CI: 1.11-1.34; p < 0.0001) were predictive factors of serious infections. Conclusions Over time, prednisone doses higher than 15 mg/day, use of methylprednisolone pulses, increase in disease activity and damage accrual were predictive of infections, whereas antimalarial use was protective against them in SLE patients.
dc.fuente.origenWOS
dc.identifier.doi10.1177/0961203319860579
dc.identifier.eissn1477-0962
dc.identifier.issn0961-2033
dc.identifier.urihttps://doi.org/10.1177/0961203319860579
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100944
dc.identifier.wosidWOS:000476251000001
dc.issue.numero9
dc.language.isoen
dc.pagina.final1110
dc.pagina.inicio1101
dc.revistaLupus
dc.rightsacceso restringido
dc.subjectSystemic lupus erythematosus
dc.subjectserious infections
dc.subjectantimalarial use
dc.subjectglucocorticoid use
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFactors predictive of serious infections over time in systemic lupus erythematosus patients: data from a multi-ethnic, multi-national, Latin American lupus cohort
dc.typeartículo
dc.volumen28
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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