Psychobiotic Effects on Anxiety Are Modulated by Lifestyle Behaviors: A Randomized Placebo-Controlled Trial on Healthy Adults

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dc.catalogadorgrr
dc.contributor.authorMorales-Torres, Ricardo
dc.contributor.authorCarrasco-Gubernatis, Cristobal
dc.contributor.authorGrasso-Cladera, Aitana
dc.contributor.authorCosmelli, Diego
dc.contributor.authorParada, Francisco J.
dc.contributor.authorPalacios-Garcia, Ismael
dc.date.accessioned2024-12-30T20:03:39Z
dc.date.available2024-12-30T20:03:39Z
dc.date.issued2023
dc.description.abstractPsychobiotics are modulators of the Microbiota-Gut-Brain Axis (MGBA) with promising benefits to mental health. Lifestyle behaviors are established modulators of both mental health and the MGBA. This randomized placebo-controlled clinical trial (NCT04823533) on healthy adults (N = 135) tested 4 weeks of probiotic supplementation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175). We assessed effects on wellbeing, quality of life, emotional regulation, anxiety, mindfulness and interoceptive awareness. We then analyzed if lifestyle behaviors modulated probiotic effectiveness. Results showed no significant effects of probiotic intake in whole sample outcomes. Correlational analyses revealed Healthy Behaviors were significantly correlated with wellbeing across scales. Moreover, the linear mixed-effects model showed that the interaction between high scores in Healthy Behaviors and probiotic intake was the single significant predictor of positive effects on anxiety, emotional regulation, and mindfulness in post-treatment outcomes. These findings highlight the relevance of controlling for lifestyle behaviors in psychobiotic and mental health research.
dc.fechaingreso.objetodigital2024-12-30
dc.fuente.origenWOS
dc.identifier.doi10.3390/nu15071706
dc.identifier.eissn2072-6643
dc.identifier.issn2072-6643
dc.identifier.scopusidSCOPUS_ID:2-s2.0-85152314075
dc.identifier.urihttps://doi.org/10.3390/nu15071706
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89396
dc.identifier.wosidWOS:000969925700001
dc.information.autorucEscuela de Psicología; Cosmelli, Diego ; 0000-0002-0012-4543; 1006520
dc.issue.numero7
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherMDPI
dc.revistaNutrients
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectMicrobiota-gut-brain axis
dc.subjectPsychobiotics
dc.subjectMental health
dc.subjectLifestyle behaviors
dc.subjectWell-being
dc.subjectMediterranean diet
dc.subjectEmbodied mind
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titlePsychobiotic Effects on Anxiety Are Modulated by Lifestyle Behaviors: A Randomized Placebo-Controlled Trial on Healthy Adults
dc.typeartículo
dc.volumen15
sipa.codpersvinculados1006520
sipa.trazabilidadWOS;2023-07-06
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