Prevalence and risk factors associated with the need for surgical intervention due to necrotizing enterocolitis in very low birth weight infants

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dc.contributor.authorBruno, Maria Ailen
dc.contributor.authorGalletti, Maria Fernanda
dc.contributor.authorDik, Pablo H. Brener
dc.contributor.authorMariani, Gonzalo L.
dc.contributor.authorGonzalez, Alvaro
dc.contributor.authorNieto, Ricardo
dc.date.accessioned2025-01-20T17:10:32Z
dc.date.available2025-01-20T17:10:32Z
dc.date.issued2024
dc.description.abstractIntroduction: Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal emergencies affecting very low birth weight (VLBW) infants with an incidence of 6-15 %. Early recognition is crucial. Mortality is high and variable (30-50 %). Those requiring surgical intervention have a higher mortality rate than those who receive medical treatment.Objectives: 1) To assess the prevalence of surgical NEC and associated risk factors 2) To compare outcomes based on the type of treatment required 3) To estimate the mortality associated with NEC and surgical NEC.Methods: A multicentre retrospective cohort study was designed (level II), including VLBW infants born between 2011 and 2020 in Centers of the Neocosur Network. A multivariate logistic regression analysis was performed to evaluate risk factors associated with the need for surgery.Results: NEC was diagnosed in 1679 (10.4 %) of 16,131 births in this period. The prevalence of surgery was 25 % (95 % CI 23-27 %). In multivariable analysis, variables associated with an increased risk of surgery requirement were birth weight <750 g (aOR 1.73-95%CI 1.2-2.5) and receiving antenatal antibiotics (aOR 1.54-95%CI 1.09-2.74). Those requiring surgery had significantly higher morbidity and mortality than the ones receiving medical treatment.Conclusion: In VLBW infants with NEC, lower birth weight and antenatal antibiotics administration were inde-pendently associated with the need for surgical intervention.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.earlhumdev.2023.105917
dc.identifier.eissn1872-6232
dc.identifier.issn0378-3782
dc.identifier.urihttps://doi.org/10.1016/j.earlhumdev.2023.105917
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91115
dc.identifier.wosidWOS:001138680300001
dc.language.isoen
dc.revistaEarly human development
dc.rightsacceso restringido
dc.subjectNecrotizing enterocolitis
dc.subjectPreterm infant
dc.subjectVery low birth weight infant
dc.subjectSurgery
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePrevalence and risk factors associated with the need for surgical intervention due to necrotizing enterocolitis in very low birth weight infants
dc.typeartículo
dc.volumen188
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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