Survival and Survival without Major Morbidity Seem to Be Consistently Better throughout Gestational Age in 24-to 30-Week Gestational Age Very-Low-Birth-Weight Female Infants Compared to Males

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dc.contributor.authorGarcia-Munoz Rodrigo, Fermin
dc.contributor.authorFabres, Jorge G.
dc.contributor.authorZozaya Nieto, Carlos
dc.contributor.authorSan Feliciano, Laura
dc.contributor.authorFigueras-Aloy, Josep
dc.contributor.authorSaenz de Pipaon, Miguel
dc.contributor.authorD'Apremont, Ivonne
dc.contributor.authorGenes de Lovera, Larissa E.
dc.contributor.authorBancalari, Aldo
dc.contributor.authorTapia, Jose L.
dc.contributor.authorVento, Maximo
dc.date.accessioned2025-01-20T21:04:17Z
dc.date.available2025-01-20T21:04:17Z
dc.date.issued2022
dc.description.abstractIntroduction: Several studies showed advantages in outcomes for very-low-birth-weight (VLBW) female infants. It has been suggested that recent advances in perinatal care might have benefited boys relatively more than girls, making differences disappear. Objectives: The aims of the study were (1) to determine if sex differences in survival and survival without morbidity in VLBW infants are still present in the context of more advanced perinatal care and (2) to know whether these differences are consistent throughout gestational age (GA). Methods: Retrospective cohort study in seven countries participating in the Spanish SEN1500 and the South American NEOCOSUR neonatal networks. We included VLBW infants 24-30 weeks' GA, born alive without major congenital anomalies (2013-2016). Major morbidity, survival, and survival without morbidity were compared between male and female infants overall and stratified by GA. Results: 10,565 patients were included: 5,620 (53.2%) males and 4,945 (46.8%) females. Female infants exhibited a lower incidence rate ratio (95% CI) of respiratory distress syndrome: 0.91 (0.88, 0.94), necrotizing enterocolitis: 0.83 (0.74, 0.93), major brain damage: 0.79 (0.72, 0.86), moderate-severe bronchopulmonary dysplasia (BPD): 0.77 (0.72, 0.83), higher survival: 1.03 (1.01, 1.05), survival without BPD: 1.11 (1.07, 1.16), survival without major brain damage: 1.05 (1.02, 1.08), and survival without major morbidity: 1.14 (1.07, 1.21). Survival and survival without morbidity were almost consistently favourable to females throughout GA. Conclusions: Our findings suggest that perinatal results continue to be favourable for VLBW female infants in the context of current perinatology, and that they are almost consistent throughout GA.
dc.description.funderSpanish Society of Neonatology (SENeo)
dc.fuente.origenWOS
dc.identifier.doi10.1159/000525589
dc.identifier.eissn1661-7819
dc.identifier.issn1661-7800
dc.identifier.urihttps://doi.org/10.1159/000525589
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93229
dc.identifier.wosidWOS:000826917200001
dc.issue.numero5
dc.language.isoen
dc.pagina.final593
dc.pagina.inicio585
dc.revistaNeonatology
dc.rightsacceso restringido
dc.subjectVery-low-birth-weight infant
dc.subjectSex
dc.subjectMorbidity
dc.subjectSurvival
dc.subjectBronchopulmonary dysplasia
dc.subjectBrain damage
dc.subjectIntraventricular haemorrhage
dc.subjectNecrotizing enterocolitis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSurvival and Survival without Major Morbidity Seem to Be Consistently Better throughout Gestational Age in 24-to 30-Week Gestational Age Very-Low-Birth-Weight Female Infants Compared to Males
dc.typeartículo
dc.volumen119
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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