Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Simple item page
dc.contributor.authorThery, Clotilde
dc.contributor.authorWitwer, Kenneth W.
dc.contributor.authorAikawa, Elena
dc.contributor.authorJose Alcaraz, Maria
dc.contributor.authorAnderson, Johnathon D.
dc.contributor.authorAndriantsitohaina, Ramaroson
dc.contributor.authorAntoniou, Anna
dc.contributor.authorArab, Tanina
dc.contributor.authorArcher, Fabienne
dc.contributor.authorAtkin-Smith, Georgia K.
dc.contributor.authorAyre, D. Craig
dc.contributor.authorBach, Jean-Marie
dc.contributor.authorBachurski, Daniel
dc.contributor.authorBaharvand, Hossein
dc.contributor.authorBalaj, Leonora
dc.contributor.authorBaldacchino, Shawn
dc.contributor.authorBauer, Natalie N.
dc.contributor.authorBaxter, Amy A.
dc.contributor.authorBebawy, Mary
dc.contributor.authorBeckham, Carla
dc.contributor.authorZavec, Apolonija Bedina
dc.contributor.authorBenmoussa, Abderrahim
dc.contributor.authorBerardi, Anna C.
dc.contributor.authorBergese, Paolo
dc.contributor.authorBielska, Ewa
dc.contributor.authorBlenkiron, Cherie
dc.contributor.authorBobis-Wozowicz, Sylwia
dc.contributor.authorBoilard, Eric
dc.contributor.authorBoireau, Wilfrid
dc.contributor.authorBongiovanni, Antonella
dc.contributor.authorBorras, Francesc E.
dc.contributor.authorBosch, Steffi
dc.contributor.authorBoulanger, Chantal M.
dc.contributor.authorBreakefield, Xandra
dc.contributor.authorBreglio, Andrew M.
dc.contributor.authorBrennan, Meadhbh A.
dc.contributor.authorBrigstock, David R.
dc.contributor.authorBrisson, Alain
dc.contributor.authorBroekman, Marike L. D.
dc.contributor.authorBromberg, Jacqueline F.
dc.contributor.authorBryl-Gorecka, Paulina
dc.contributor.authorBuch, Shilpa
dc.contributor.authorBuck, Amy H.
dc.contributor.authorBurger, Dylan
dc.contributor.authorBusatto, Sara
dc.contributor.authorBuschmann, Dominik
dc.contributor.authorBussolati, Benedetta
dc.contributor.authorBuzas, Edit, I
dc.contributor.authorByrd, James Bryan
dc.contributor.authorCamussi, Giovanni
dc.contributor.authorCarter, David R. F.
dc.contributor.authorCaruso, Sarah
dc.contributor.authorChamley, Lawrence W.
dc.contributor.authorChang, Yu-Ting
dc.contributor.authorChen, Chihchen
dc.contributor.authorChen, Shuai
dc.contributor.authorCheng, Lesley
dc.contributor.authorChin, Andrew R.
dc.contributor.authorClayton, Aled
dc.contributor.authorClerici, Stefano P.
dc.contributor.authorCocks, Alex
dc.contributor.authorCocucci, Emanuele
dc.contributor.authorCoffey, Robert J.
dc.contributor.authorCordeiro-da-Silva, Anabela
dc.contributor.authorCouch, Yvonne
dc.contributor.authorCoumans, Frank A. W.
dc.contributor.authorCoyle, Beth
dc.contributor.authorCrescitelli, Rossella
dc.contributor.authorCriado, Miria Ferreira
dc.contributor.authorD'Souza-Schorey, Crislyn
dc.contributor.authorDas, Saumya
dc.contributor.authorChaudhuri, Amrita Datta
dc.contributor.authorde Candia, Paola
dc.contributor.authorDe Santana Junior, Eliezer F.
dc.contributor.authorDe Wever, Olivier
dc.contributor.authordel Portillo, Hernando A.
dc.contributor.authorDemaret, Tanguy
dc.contributor.authorDeville, Sarah
dc.contributor.authorDevitt, Andrew
dc.contributor.authorDhondt, Bert
dc.contributor.authorDi Vizio, Dolores
dc.contributor.authorDieterich, Lothar C.
dc.contributor.authorDolo, Vincenza
dc.contributor.authorDominguez Rubio, Ana Paula
dc.contributor.authorDominici, Massimo
dc.contributor.authorDourado, Mauricio R.
dc.contributor.authorDriedonks, Tom A. P.
dc.contributor.authorDuarte, Filipe, V
dc.contributor.authorDuncan, Heather M.
dc.contributor.authorEichenberger, Ramon M.
dc.contributor.authorEkstrom, Karin
dc.contributor.authorAndaloussi, Samir E. L.
dc.contributor.authorElie-Caille, Celine
dc.contributor.authorErdbrugger, Uta
dc.contributor.authorFalcon-Perez, Juan M.
dc.contributor.authorFatima, Farah
dc.contributor.authorFish, Jason E.
dc.contributor.authorFlores-Bellver, Miguel
dc.contributor.authorForsonits, Andras
dc.contributor.authorFrelet-Barrand, Annie
dc.contributor.authorFricke, Fabia
dc.contributor.authorFuhrmann, Gregor
dc.contributor.authorGabrielsson, Susanne
dc.contributor.authorGamez-Valero, Ana
dc.contributor.authorGardiner, Chris
dc.contributor.authorGaertner, Kathrin
dc.contributor.authorGaudin, Raphael
dc.contributor.authorGho, Yong Song
dc.contributor.authorGiebel, Bernd
dc.contributor.authorGilbert, Caroline
dc.contributor.authorGimona, Mario
dc.contributor.authorGiusti, Ilaria
dc.contributor.authorGoberdhan, Deborah C., I
dc.contributor.authorGoergens, Andre
dc.contributor.authorGorski, Sharon M.
dc.contributor.authorGreening, David W.
dc.contributor.authorGross, Julia Christina
dc.contributor.authorGualerzi, Alice
dc.contributor.authorGupta, Gopal N.
dc.contributor.authorGustafson, Dakota
dc.contributor.authorHandberg, Aase
dc.contributor.authorHaraszti, Reka A.
dc.contributor.authorHarrison, Paul
dc.contributor.authorHegyesi, Hargita
dc.contributor.authorHendrix, An
dc.contributor.authorHill, Andrew F.
dc.contributor.authorHochberg, Fred H.
dc.contributor.authorHoffmann, Karl F.
dc.contributor.authorHolder, Beth
dc.contributor.authorHolthofer, Harry
dc.contributor.authorHosseinkhani, Baharak
dc.contributor.authorHu, Guoku
dc.contributor.authorHuang, Yiyao
dc.contributor.authorHuber, Veronica
dc.contributor.authorHunt, Stuart
dc.contributor.authorIbrahim, Ahmed Gamal-Eldin
dc.contributor.authorIkezu, Tsuneya
dc.contributor.authorInal, Jameel M.
dc.contributor.authorIsin, Mustafa
dc.contributor.authorIvanova, Alena
dc.contributor.authorJackson, Hannah K.
dc.contributor.authorJacobsen, Soren
dc.contributor.authorJay, Steven M.
dc.contributor.authorJayachandran, Muthuvel
dc.contributor.authorJenster, Guido
dc.contributor.authorJiang, Lanzhou
dc.contributor.authorJohnson, Suzanne M.
dc.contributor.authorJones, Jennifer C.
dc.contributor.authorJong, Ambrose
dc.contributor.authorJovanovic-Talisman, Tijana
dc.contributor.authorJung, Stephanie
dc.contributor.authorKalluri, Raghu
dc.contributor.authorKano, Shin-ichi
dc.contributor.authorKaur, Sukhbir
dc.contributor.authorKawamura, Yumi
dc.contributor.authorKeller, Evan T.
dc.contributor.authorKhamari, Delaram
dc.contributor.authorKhomyakova, Elena
dc.contributor.authorKhvorova, Anastasia
dc.contributor.authorKierulf, Peter
dc.contributor.authorKim, Kwang Pyo
dc.contributor.authorKislinger, Thomas
dc.contributor.authorKlingeborn, Mikael
dc.contributor.authorKlinke, David J., II
dc.contributor.authorKornek, Miroslaw
dc.contributor.authorKosanovic, Maja M.
dc.contributor.authorKovacs, Arpad Ferenc
dc.contributor.authorKraemer-Albers, Eva-Maria
dc.contributor.authorKrasemann, Susanne
dc.contributor.authorKrause, Mirja
dc.contributor.authorKurochkin, Igor, V
dc.contributor.authorKusuma, Gina D.
dc.contributor.authorKuypers, Soren
dc.contributor.authorLaitinen, Saara
dc.contributor.authorLangevin, Scott M.
dc.contributor.authorLanguino, Lucia R.
dc.contributor.authorLannigan, Joanne
dc.contributor.authorLasser, Cecilia
dc.contributor.authorLaurent, Louise C.
dc.contributor.authorLavieu, Gregory
dc.contributor.authorLazaro-Ibanez, Elisa
dc.contributor.authorLe Lay, Soazig
dc.contributor.authorLee, Myung-Shin
dc.contributor.authorLee, Yi Xin Fiona
dc.contributor.authorLemos, Debora S.
dc.contributor.authorLenassi, Metka
dc.contributor.authorLeszczynska, Aleksandra
dc.contributor.authorLi, Isaac T. S.
dc.contributor.authorLiao, Ke
dc.contributor.authorLibregts, Sten F.
dc.contributor.authorLigeti, Erzsebet
dc.contributor.authorLim, Rebecca
dc.contributor.authorLim, Sai Kiang
dc.contributor.authorLine, Aija
dc.contributor.authorLinnemannstoens, Karen
dc.contributor.authorLlorente, Alicia
dc.contributor.authorLombard, Catherine A.
dc.contributor.authorLorenowicz, Magdalena J.
dc.contributor.authorLorincz, Akos M.
dc.contributor.authorLotvall, Jan
dc.contributor.authorLovett, Jason
dc.contributor.authorLowry, Michelle C.
dc.contributor.authorLoyer, Xavier
dc.contributor.authorLu, Quan
dc.contributor.authorLukomska, Barbara
dc.contributor.authorLunavat, Taral R.
dc.contributor.authorMaas, Sybren L. N.
dc.contributor.authorMalhi, Harmeet
dc.contributor.authorMarcilla, Antonio
dc.contributor.authorMariani, Jacopo
dc.contributor.authorMariscal, Javier
dc.contributor.authorMartens-Uzunova, Elena S.
dc.contributor.authorMartin-Jaular, Lorena
dc.contributor.authorMartinez, M. Carmen
dc.contributor.authorMartins, Vilma Regina
dc.contributor.authorMathieu, Mathilde
dc.contributor.authorMathivanan, Suresh
dc.contributor.authorMaugeri, Marco
dc.contributor.authorMcGinnis, Lynda K.
dc.contributor.authorMcVey, Mark J.
dc.contributor.authorMeckes, David G., Jr.
dc.contributor.authorMeehan, Katie L.
dc.contributor.authorMertens, Inge
dc.contributor.authorMinciacchi, Valentina R.
dc.contributor.authorMoller, Andreas
dc.contributor.authorJorgensen, Malene Moller
dc.contributor.authorMorales-Kastresana, Aizea
dc.contributor.authorMorhayim, Jess
dc.contributor.authorMullier, Francois
dc.contributor.authorMuraca, Maurizio
dc.contributor.authorMusante, Luca
dc.contributor.authorMussack, Veronika
dc.contributor.authorMuth, Dillon C.
dc.contributor.authorMyburgh, Kathryn H.
dc.contributor.authorNajrana, Tanbir
dc.contributor.authorNawaz, Muhammad
dc.contributor.authorNazarenko, Irina
dc.contributor.authorNejsum, Peter
dc.contributor.authorNeri, Christian
dc.contributor.authorNeri, Tommaso
dc.contributor.authorNieuwland, Rienk
dc.contributor.authorNimrichter, Leonardo
dc.contributor.authorNolan, John P.
dc.contributor.authorNolte-'t Hoen, Esther N. M.
dc.contributor.authorNoren Hooten, Nicole
dc.contributor.authorO'Driscoll, Lorraine
dc.contributor.authorO'Grady, Tina
dc.contributor.authorO'Loghlen, Ana
dc.contributor.authorOchiya, Takahiro
dc.contributor.authorOlivier, Martin
dc.contributor.authorOrtiz, Alberto
dc.contributor.authorOrtiz, Luis A.
dc.contributor.authorOsteikoetxea, Xabier
dc.contributor.authorOstegaard, Ole
dc.contributor.authorOstrowski, Matias
dc.contributor.authorPark, Jaesung
dc.contributor.authorPegtel, D. Michiel
dc.contributor.authorPeinado, Hector
dc.contributor.authorPerut, Francesca
dc.contributor.authorPfaffl, Michael W.
dc.contributor.authorPhinney, Donald G.
dc.contributor.authorPieters, Bartijn C. H.
dc.contributor.authorPink, Ryan C.
dc.contributor.authorPisetsky, David S.
dc.contributor.authorvon Strandmann, Elke Pogge
dc.contributor.authorPolakovicova, Iva
dc.contributor.authorPoon, Ivan K. H.
dc.contributor.authorPowell, Bonita H.
dc.contributor.authorPrada, Ilaria
dc.contributor.authorPulliam, Lynn
dc.contributor.authorQuesenberry, Peter
dc.contributor.authorRadeghieri, Annalisa
dc.contributor.authorRaffai, Robert L.
dc.contributor.authorRaimondo, Stefania
dc.contributor.authorRak, Janusz
dc.contributor.authorRamirez, Marcel, I
dc.contributor.authorRaposo, Graca
dc.contributor.authorRayyan, Morsi S.
dc.contributor.authorRegev-Rudzki, Neta
dc.contributor.authorRicklefs, Franz L.
dc.contributor.authorRobbins, Paul D.
dc.contributor.authorRoberts, David D.
dc.contributor.authorRodrigues, Silvia C.
dc.contributor.authorRohde, Eva
dc.contributor.authorRome, Sophie
dc.contributor.authorRouschop, Kasper M. A.
dc.contributor.authorRughetti, Aurelia
dc.contributor.authorRussell, Ashley E.
dc.contributor.authorSaa, Paula
dc.contributor.authorSahoo, Susmita
dc.contributor.authorSalas-Huenuleo, Edison
dc.contributor.authorSanchez, Catherine
dc.contributor.authorSaugstad, Julie A.
dc.contributor.authorSaul, Meike J.
dc.contributor.authorSchiffelers, Raymond M.
dc.contributor.authorSchneider, Raphael
dc.contributor.authorSchoyen, Tine Hiorth
dc.contributor.authorScott, Aaron
dc.contributor.authorShahaj, Eriomina
dc.contributor.authorSharma, Shivani
dc.contributor.authorShatnyeva, Olga
dc.contributor.authorShekari, Faezeh
dc.contributor.authorShelke, Ganesh Vilas
dc.contributor.authorShetty, Ashok K.
dc.contributor.authorShiba, Kiyotaka
dc.contributor.authorSiljander, Pia R-M
dc.contributor.authorSilva, Andreia M.
dc.contributor.authorSkowronek, Agata
dc.contributor.authorSnyder, Orman L., II
dc.contributor.authorSoares, Rodrigo Pedro
dc.contributor.authorSodar, Barbara W.
dc.contributor.authorSoekmadji, Carolina
dc.contributor.authorSotillo, Javier
dc.contributor.authorStahl, Philip D.
dc.contributor.authorStoorvogel, Willem
dc.contributor.authorStott, Shannon L.
dc.contributor.authorStrasser, Erwin F.
dc.contributor.authorSwift, Simon
dc.contributor.authorTahara, Hidetoshi
dc.contributor.authorTewari, Muneesh
dc.contributor.authorTimms, Kate
dc.contributor.authorTiwari, Swasti
dc.contributor.authorTixeira, Rochelle
dc.contributor.authorTkach, Mercedes
dc.contributor.authorToh, Wei Seong
dc.contributor.authorTomasini, Richard
dc.contributor.authorTorrecilhas, Ana Claudia
dc.contributor.authorPablo Tosar, Juan
dc.contributor.authorToxavidis, Vasilis
dc.contributor.authorUrbanelli, Lorena
dc.contributor.authorVader, Pieter
dc.contributor.authorvan Balkom, Bas W. M.
dc.contributor.authorvan der Grein, Susanne G.
dc.contributor.authorVan Deun, Jan
dc.contributor.authorvan Herwijnen, Martijn J. C.
dc.contributor.authorVan Keuren-Jensen, Kendall
dc.contributor.authorvan Niel, Guillaume
dc.contributor.authorvan Royen, Martin E.
dc.contributor.authorvan Wijnen, Andre J.
dc.contributor.authorHelena Vasconcelos, M.
dc.contributor.authorVechetti, Ivan J., Jr.
dc.contributor.authorVeit, Tiago D.
dc.contributor.authorVella, Laura J.
dc.contributor.authorVelot, Emilie
dc.contributor.authorVerweij, Frederik J.
dc.contributor.authorVestad, Beate
dc.contributor.authorVinas, Jose L.
dc.contributor.authorVisnovitz, Tamas
dc.contributor.authorVukman, Krisztina V.
dc.contributor.authorWahlgren, Jessica
dc.contributor.authorWatson, Dionysios C.
dc.contributor.authorWauben, Marca H. M.
dc.contributor.authorWeaver, Alissa
dc.contributor.authorWebber, Jason P.
dc.contributor.authorWeber, Viktoria
dc.contributor.authorWehman, Ann M.
dc.contributor.authorWeiss, Daniel J.
dc.contributor.authorWelsh, Joshua A.
dc.contributor.authorWendt, Sebastian
dc.contributor.authorWheelock, Asa M.
dc.contributor.authorWiener, Zoltan
dc.contributor.authorWitte, Leonie
dc.contributor.authorWolfram, Joy
dc.contributor.authorXagorari, Angeliki
dc.contributor.authorXander, Patricia
dc.contributor.authorXu, Jing
dc.contributor.authorYan, Xiaomei
dc.contributor.authorYanez-Mo, Maria
dc.contributor.authorYin, Hang
dc.contributor.authorYuana, Yuana
dc.contributor.authorZappulli, Valentina
dc.contributor.authorZarubova, Jana
dc.contributor.authorZekas, Vytautas
dc.contributor.authorZhang, Jian-ye
dc.contributor.authorZhao, Zezhou
dc.contributor.authorZheng, Lei
dc.contributor.authorZheutlin, Alexander R.
dc.contributor.authorZickler, Antje M.
dc.contributor.authorZimmermann, Pascale
dc.contributor.authorZivkovic, Angela M.
dc.contributor.authorZocco, Davide
dc.contributor.authorZuba-Surma, Ewa K.
dc.date.accessioned2025-01-23T21:21:39Z
dc.date.available2025-01-23T21:21:39Z
dc.date.issued2018
dc.description.abstractThe last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
dc.fuente.origenWOS
dc.identifier.doi10.1080/20013078.2018.1535750
dc.identifier.eissn2001-3078
dc.identifier.urihttps://doi.org/10.1080/20013078.2018.1535750
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101233
dc.identifier.wosidWOS:000452068900001
dc.issue.numero1
dc.language.isoen
dc.revistaJournal of extracellular vesicles
dc.rightsacceso restringido
dc.subjectextracellular vesicles
dc.subjectexosomes
dc.subjectectosomes
dc.subjectmicrovesicles
dc.subjectminimal information requirements
dc.subjectguidelines
dc.subjectstandardization
dc.subjectmicroparticles
dc.subjectrigor
dc.subjectreproducibility
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMinimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
dc.typeartículo
dc.volumen7
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas