MODULATION OF DENDRITIC RELEASE OF DOPAMINE BY N-METHYL-D-ASPARTATE RECEPTORS IN RAT SUBSTANTIA NIGRA

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dc.contributor.authorARANEDA, R
dc.contributor.authorBUSTOS, G
dc.date.accessioned2025-01-23T19:24:07Z
dc.date.available2025-01-23T19:24:07Z
dc.date.issued1989
dc.description.abstractA superfusion system was used to study the effects of excitatory amino acids (EAA) on release of [3H]dopamine ([3H]DPA) previously taken up by rat substantia nigra (SN) slices. The EAA tested (20-250 .mu.M), with the exception of quisqualate and kainate, markedly evoked [3H]DA release from nigral slices when Mg2+ ions were omitted from the superfusion medium. The EAA receptor agonists exhibited the following relative potency in stimulating [3H]DA release: L-glutamate (1-Glu) > N-methyl-D-aspartate (NMDA) > NM(D,L)A > D-Glu .mchgt. quisqualate = kainate. D-2-Amino-5-phosphonovalerate (100-200 .mu.M), an antagonists for NMDA receptors, substantially reduced [3H]DA release evoked by L-Glu or NMDA. In contrast, L-Glu diethyl ester (100-200 .mu.M) produced a lesser blocking effect on [3H]DA release evoked by the EAA. Further experiments showed that the NMDA-mediated release of [3H]DA was totally suppressed by the omission of Ca2+ or by the addition of tetrodotoxin (0.1 .mu.M) to the superfusion medium. In addition, strychnine, an antagonist for glycine (Gly) receptors, significantly decreased NMDA (100 .mu.M)-evoked as well as glycine (100 .mu.M)-evoked release of [3H]DA from nigral slices. The results shown support the idea that activation of NMDA subtype receptors in SN may trigger a Ca2+-dependent release of DA from dendrites of nigro-striatal DA-containing neurons. Furthermore, a transsynaptic mechanism that may partially involve Gly-containing interneurons is proposed to account for some of the events mediating NMDA receptor activation and DA release in SN.
dc.fuente.origenWOS
dc.identifier.eissn1471-4159
dc.identifier.issn0022-3042
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99313
dc.identifier.wosidWOS:A1989T290700043
dc.issue.numero3
dc.language.isoen
dc.pagina.final970
dc.pagina.inicio962
dc.revistaJournal of neurochemistry
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMODULATION OF DENDRITIC RELEASE OF DOPAMINE BY N-METHYL-D-ASPARTATE RECEPTORS IN RAT SUBSTANTIA NIGRA
dc.typeartículo
dc.volumen52
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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