One-year Mortality of Cancer Patients with an Unplanned ICU Admission: A Cohort Analysis Between 2008 and 2017 in the Netherlands

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dc.contributor.authorvan der Zee, Esther N.
dc.contributor.authorTermorshuizen, Fabian
dc.contributor.authorBenoit, Dominique D.
dc.contributor.authorde Keizer, Nicolette F.
dc.contributor.authorBakker, Jan
dc.contributor.authorKompanje, Erwin J. O.
dc.contributor.authorRietdijk, Wim J. R.
dc.contributor.authorEpker, Jelle L.
dc.date.accessioned2025-01-20T22:01:32Z
dc.date.available2025-01-20T22:01:32Z
dc.date.issued2022
dc.description.abstractIntroduction: A decrease in short-term mortality of critically ill cancer patients with an unplanned intensive care unit (ICU) admission has been described. Few studies describe a change over time of 1-year mortality. Therefore, we examined the 1-year mortality of cancer patients (hematological or solid) with an unplanned ICU admission and we described whether the mortality changed over time. Methods: We used the National Intensive Care Evaluation (NICE) registry and extracted all patients with an unplanned ICU admission in the Netherlands between 2008 and 2017. The primary outcome was 1-year mortality, analyzed with a mixed-effects Cox proportional hazard regression. We compared the 1-year mortality of cancer patients to that of patients without cancer. Furthermore, we examined changes in mortality over the study period. Results: We included 470,305 patients: 10,401 with hematological cancer, 35,920 with solid cancer, and 423,984 without cancer. The 1-year mortality rates were 60.1%, 46.2%, and 28.3% respectively (P< .01). Approximately 30% of the cancer patients surviving their hospital admission died within 1 year, this was 12% in patients without cancer. In hematological patients, 1-year mortality decreased between 2008 and 2011, after which it stabilized. In solid cancer patients, inspection showed neither an increasing nor decreasing trend over the inclusion period. For patients without cancer, 1-year mortality decreased between 2008 and 2013, after which it stabilized. A clear decrease in hospital mortality was seen within all three groups. Conclusion: The 1-year mortality of cancer patients with an unplanned ICU admission (hematological and solid) was higher than that of patients without cancer. About one-third of the cancer patients surviving their hospital admission died within 1 year after ICU admission. We found a decrease in 1-year mortality until 2011 in hematology patients and no decrease in solid cancer patients. Our results suggest that for many cancer patients, an unplanned ICU admission is still a way to recover from critical illness, and it does not necessarily lead to success in long-term survival. The underlying type of malignancy is an important factor for long-term outcomes in patients recovering from critical illness.
dc.fuente.origenWOS
dc.identifier.doi10.1177/08850666211054369
dc.identifier.eissn1525-1489
dc.identifier.issn0885-0666
dc.identifier.urihttps://doi.org/10.1177/08850666211054369
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93845
dc.identifier.wosidWOS:000720926700001
dc.issue.numero9
dc.language.isoen
dc.pagina.final1173
dc.pagina.inicio1165
dc.revistaJournal of intensive care medicine
dc.rightsacceso restringido
dc.subjectintensive care unit
dc.subjectcritical care
dc.subjectmalignancy
dc.subjectcancer
dc.subjectneoplasm
dc.subjectICU admission
dc.subjectmortality
dc.subjectsurvival
dc.subjecttime trend
dc.subjectICU triage
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOne-year Mortality of Cancer Patients with an Unplanned ICU Admission: A Cohort Analysis Between 2008 and 2017 in the Netherlands
dc.typeartículo
dc.volumen37
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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