NEUROTROPHIC EFFECTS - AXOPLASMIC-TRANSPORT INVOLVEMENT IN REGULATION OF SKELETAL-MUSCLE SOLUBLE-PROTEINS
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1976
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Abstract
Skeletal muscle soluble proteins were assayed by polyacrylamide gel disc-electrophoresis at different times (4-36 days) after injection of 10 mM colchicine into the motor nerve [of cats] and after denervation. Effects of drug-induced axoplasmic transport blockage differed from those of denervation as to quantitative changes in the protein concentration of certain bands. Axoplasmic transport is apparently involved in the neural control of a number of muscle proteins. This does not invalidate the participation of acetylcholine and muscle activity in the regulation of muscle metabolism.