AXONAL SPROUTING INDUCED IN THE SCIATIC-NERVE BY THE AMYLOID PRECURSOR PROTEIN (APP) AND OTHER ANTIPROTEASES

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dc.contributor.authorALVAREZ, J
dc.contributor.authorMORENO, RD
dc.contributor.authorLLANOS, O
dc.contributor.authorINESTROSA, NC
dc.contributor.authorBRANDAN, E
dc.contributor.authorCOLBY, T
dc.contributor.authorESCH, FS
dc.date.accessioned2025-01-23T19:22:02Z
dc.date.available2025-01-23T19:22:02Z
dc.date.issued1992
dc.description.abstractProtease inhibition is the mechanism by which some trophic factors promote the extension of neurites. In the rat sciatic nerve, we assessed the ability to induce sprouts of the APP isoform that embodies the Kunitz antiprotease domain and other antiproteases. With the electron microscope, axonal sprouts were found when antiproteases were supplied but not after administration of inactive substances. We conclude that axons have a drive to sprout which can be released by the unbalance of an extracellular protease antiprotease system. We propose that this system is involved in the pathogenesis of Alzheimer's disease.
dc.fuente.origenWOS
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98941
dc.identifier.wosidWOS:A1992JQ14400032
dc.issue.numero1-2
dc.language.isoen
dc.pagina.final134
dc.pagina.inicio130
dc.revistaNeuroscience letters
dc.rightsacceso restringido
dc.subjectALZHEIMER
dc.subjectLEUPEPTIN
dc.subjectAPROTININ
dc.subjectTROPHISM
dc.subjectNEURITE
dc.subjectKUNITZ
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAXONAL SPROUTING INDUCED IN THE SCIATIC-NERVE BY THE AMYLOID PRECURSOR PROTEIN (APP) AND OTHER ANTIPROTEASES
dc.typeartículo
dc.volumen144
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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