Canakinumab in addition to phosphate-binding and phosphaturia-inducing therapy were effective in achieving remission in a child with a large familial calcinotic tumour

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dc.contributor.authorOchoa, Maria
dc.contributor.authorJurencak, Roman
dc.contributor.authorSmit, Kevin
dc.contributor.authorCarsen, Sasha
dc.contributor.authorSawyer, Sarah L.
dc.contributor.authorRobinson, Marie -Eve
dc.contributor.authorKhatchadourian, Karine
dc.contributor.authorCheng, Hooi Peng
dc.contributor.authorPag, Marika
dc.contributor.authorWerier, Joel
dc.contributor.authorWard, Leanne Marie
dc.date.accessioned2025-01-20T20:07:53Z
dc.date.available2025-01-20T20:07:53Z
dc.date.issued2023
dc.description.abstractWe describe the clinical evolution of a patient with tumoral calcinosis due to a pathogenic variant in the GALNT3 gene presented with a large mass overlying her left hip associated complicated by inflammatory flares. Therapy (sevelamer, acetazolamide, and probenecid) was unsuccessful in preventing tumour surgeries, therefore, interleukin-1 & beta; monoclonal antibody therapy was added; this was successful in the prevention of tumour re-growth. This case highlights the importance of assessing and treating the inflammatory aspect of calcinotic tumour.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bonr.2023.101695
dc.identifier.issn2352-1872
dc.identifier.urihttps://doi.org/10.1016/j.bonr.2023.101695
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91857
dc.identifier.wosidWOS:001043566100001
dc.language.isoen
dc.revistaBone reports
dc.rightsacceso restringido
dc.subjectAcetazolamide
dc.subjectFamilial tumoral calcinosis
dc.subjectGLANT3 mutation
dc.subjectSevelamer
dc.subjectAnti-IL1 beta antibody
dc.subjectProbenecid
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCanakinumab in addition to phosphate-binding and phosphaturia-inducing therapy were effective in achieving remission in a child with a large familial calcinotic tumour
dc.typeartículo
dc.volumen19
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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