In vivo imaging characterization of basal cell carcinoma and cutaneous response to high-dose ionizing radiation therapy: A prospective study of reflectance confocal microscopy, dermoscopy, and ultrasonography

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dc.contributor.authorNavarrete-Dechent, Cristian
dc.contributor.authorCordova, Miguel
dc.contributor.authorLiopyris, Konstantinos
dc.contributor.authorAleissa, Saud
dc.contributor.authorRajadhyaksha, Milind
dc.contributor.authorCohen, Gil'ad
dc.contributor.authorMarghoob, Ashfaq A.
dc.contributor.authorRossi, Anthony M.
dc.contributor.authorBarker, Christopher A.
dc.date.accessioned2025-01-20T22:19:26Z
dc.date.available2025-01-20T22:19:26Z
dc.date.issued2021
dc.description.abstractBackground: Radiation therapy (RT) is a treatment option for select skin cancers. The histologic effects of RT on normal skin or skin cancers are not well characterized. Dermoscopy, high-frequency ultrasonography (HFUS), and reflectance confocal microscopy (RCM) are noninvasive imaging modalities that may help characterize RT response.
dc.description.abstractObjectives: To describe changes in the tumor and surrounding skin of patients with basal cell carcinoma (BCC) treated with RT.
dc.description.abstractMethods: The study was conducted between 2014 and 2018. Patients with biopsy-proven BCCs were treated with 42 Gy in 6 fractions using a commercially available brachytherapy device. Dermoscopy, HFUS, and RCM were performed before treatment and at 6 weeks, 3 months, and 12 months after RT.
dc.description.abstractResults: A total of 137 imaging assessments (RCM 1 dermoscopy 1 HFUS) were performed in 12 patients. BCC-specific features were present in 81.8%, 91%, and 17% of patients imaged with dermoscopy, RCM, and HFUS at baseline, respectively, before treatment. After treatment, the resolution of these features was noted in 33.4%, 91.7%, and 100% of patients imaged with the respective modalities. No recurrences were seen after a mean of 31.7 months of follow-up.
dc.description.abstractLimitations: Small sample size and no histopathologic correlation.
dc.description.abstractConclusion: Dermoscopy and HFUS were not as reliable as RCM at characterizing BCC RT response.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jaad.2020.07.130
dc.identifier.eissn1097-6787
dc.identifier.issn0190-9622
dc.identifier.urihttps://doi.org/10.1016/j.jaad.2020.07.130
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94596
dc.identifier.wosidWOS:000661275800040
dc.issue.numero6
dc.language.isoen
dc.pagina.final1584
dc.pagina.inicio1575
dc.revistaJournal of the american academy of dermatology
dc.rightsacceso restringido
dc.subjectbasal cell carcinoma
dc.subjectbrachytherapy
dc.subjectdermatoscopy
dc.subjectdermoscopy
dc.subjectradiation therapy
dc.subjectradiotherapy
dc.subjectreflectance confocal microscopy
dc.subjectsurgery
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIn vivo imaging characterization of basal cell carcinoma and cutaneous response to high-dose ionizing radiation therapy: A prospective study of reflectance confocal microscopy, dermoscopy, and ultrasonography
dc.typeartículo
dc.volumen84
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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