Alcohol Intake Thresholds Among Individuals With Steatotic Liver Disease

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dc.article.numberem2357
dc.contributor.authorYeo Y.H.
dc.contributor.authorZhu Y.
dc.contributor.authorArab J.P.
dc.contributor.authorNi W.
dc.contributor.authorXu X.
dc.contributor.authorShi J.
dc.contributor.authorLi J.
dc.contributor.otherCEDEUS (Chile)
dc.date.accessioned2025-05-01T10:33:22Z
dc.date.available2025-05-01T10:33:22Z
dc.date.issued2023
dc.description.abstractThe complex interplay between dietary factors, inflammation, and macrophage polarization is pivotal in the pathogenesis and progression of chronic liver diseases (CLDs). Omega-3 fatty acids (FAs) have brought in attention due to their potential to modulate inflammation and exert protective effects in various pathological conditions. Omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have shown promise in mitigating inflammation and enhancing the resolution of inflammatory responses. They influence the M1/M2 macrophage phenotype balance, promoting a shift towards the M2 anti-inflammatory phenotype. Specialized pro-resolving mediators (SPMs), such as resolvins (Rvs), protectins (PDs), and maresins (MaRs), have emerged as potent regulators of inflammation and macrophage polarization. They show anti-inflammatory and pro-resolving properties, by modulating the expression of cytokines, facilitate the phagocytosis of apoptotic cells, and promote tissue repair. MaR1, in particular, has demonstrated significant hepatoprotective effects by promoting M2 macrophage polarization, reducing oxidative stress, and inhibiting key inflammatory pathways such as NF-kappa B. In the context of CLDs, such as nonalcoholic fatty liver disease (NAFLD) and cirrhosis, omega-3s and their SPMs have shown promise in attenuating liver injury, promoting tissue regeneration, and modulating macrophage phenotypes. The aim of this article was to analyze the emerging role of omega-3 FAs and their SPMs in the context of macrophage polarization, with special interest in the mechanisms underlying their effects and their interactions with other cell types within the liver microenvironment, focused on CLDs and the development of novel therapeutic strategies.
dc.description.funderChilean National Fund for Scientific and Technological Development Fondecyt, Iniciacion Grant
dc.format.extent18 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1001/jamanetworkopen.2023.47548
dc.identifier.eisbn9780128194706
dc.identifier.eissn1422-0067
dc.identifier.isbn9783031764011
dc.identifier.issn25743805
dc.identifier.pubmedid40156360
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85179774992
dc.identifier.urihttps://doi.org/10.1001/jamanetworkopen.2023.47548
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103995
dc.identifier.wosidWOS:001126163600007
dc.information.autorucEscuela de Medicina; Arab Verdugo Juan Pablo; 0000-0002-8561-396X; 132745
dc.issue.numero21
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final119
dc.pagina.inicio113
dc.publisherSpringer
dc.relation.ispartofIntersections Interdisciplinary Research on Architecture, Design, City and Territory
dc.revistaJAMA network open
dc.rightsacceso restringido
dc.subjectchronic liver disease
dc.subjectspecialized pro-resolving mediators
dc.subjectinflammation
dc.subjectmacrophages M1/M2 polarization
dc.subjectimmunometabolism
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAlcohol Intake Thresholds Among Individuals With Steatotic Liver Disease
dc.typeartículo
dc.volumen6
sipa.codpersvinculados132745
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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