Differential regulation of μ-opioid receptor mRNA in the nucleus accumbens shell and core accompanying amphetamine behavioral sensitization

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dc.contributor.authorVecchiola, A
dc.contributor.authorCollyer, P
dc.contributor.authorFigueroa, R
dc.contributor.authorLabarca, R
dc.contributor.authorBustos, G
dc.contributor.authorMagendzo, K
dc.date.accessioned2025-01-21T01:32:04Z
dc.date.available2025-01-21T01:32:04Z
dc.date.issued1999
dc.description.abstractRepeated amphetamine (AMPH) administration results in behavioral sensitization. To investigate the participation of the opioid system in this phenomenon, we examined the effects of acute and repeated AMPH administration on mu-opioid receptor (MOR) mRNA levels in the nucleus accumbens (NAc) and striatum (STR) of rats, by quantitative non-radioactive in situ hybridization. Five injections of PAh IPH (1.5 mg kg(-1), i.p., once every other day), resulted in a sensitization response profile and a significant down-regulation of MOR mRNA levels in the NAc shell, whereas no change was observed in MOR mRNA levels in the NAc core compared to the saline controls. Conversely, MOR mRNA levels were up-regulated in the rostral STR of AMPH-sensitized rats compared to saline controls. No changes in MOR mRNA levels were observed after acute AMPH treatment in any of the brain regions studied. These results suggest that the opioid system participates in the neurobiological underpinnings of behavioral sensitization and that opioid receptor (OR) expression in the STR and NAc shell and core is differentially modulated by repeated AMPH exposure. (C) 1999 Elsevier Science B.V. All rights reserved.
dc.fuente.origenWOS
dc.identifier.issn0169-328X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97198
dc.identifier.wosidWOS:000080577100001
dc.issue.numero1
dc.language.isoen
dc.pagina.final9
dc.pagina.inicio1
dc.revistaMolecular brain research
dc.rightsacceso restringido
dc.subjectmu-opioid receptor mRNA
dc.subjectamphetamine behavioral sensitization
dc.subjectnon-radioactive in situ hybridization
dc.subjectnucleus accumbens shell
dc.subjectstriatum
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDifferential regulation of μ-opioid receptor mRNA in the nucleus accumbens shell and core accompanying amphetamine behavioral sensitization
dc.typeartículo
dc.volumen69
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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