Evaluación de métodos diagnósticos para sífilis congénita

Simple item page
dc.catalogadorjlo
dc.contributor.authorSalazar J., Aurora
dc.contributor.authorPerret P., Cecilia
dc.contributor.authorChávez P., Ana
dc.contributor.authorGarcia C., Patricia
dc.contributor.authorMillan O., Zunilda
dc.contributor.authorGoycoolea M., Manuela
dc.contributor.authorParada B., Jacqueline
dc.contributor.authorUrra M., Liliana
dc.contributor.authorAhumada H., Eugenia
dc.contributor.authorYoma B., M. Teresa
dc.contributor.authorDuque O., Clara
dc.contributor.authorHerman L., Odette
dc.contributor.authorQuiroga G., Teresa
dc.date.accessioned2024-01-29T17:48:29Z
dc.date.available2024-01-29T17:48:29Z
dc.date.issued2000
dc.description.abstractCongenital syphilis is a relevant problem in our country. At the present, no routine method is available to verify the diagnostic. This multicenter prospective study recruited serum samples reactive for VDRL of sixty mothers with their respective infant (n = 120). In addition to the routinely used screening assay (RPR, VDRL) the following tests were performed: serological detection of specific antibodies to Treponema pallidum for IgM ( Pathozyme®, Captia® IgM), for IgG (Captia® IgG) and for IgG/IgM ( MHA-TP; Pathozyme competition®, ICE Syphilis®, Determine®). A good agreement was observed between the immunoassays for IgG alone or IgG/IgM (90%) and for IgM alone or IgG/IgM (87.5%). Every mother who had syphilis in the moment of the study or had had syphilis before, and her newborn child, were positive for IgG. Only 64% of the mothers with adequate treatment during their pregnancy had a positive titer for IgM and all of their newborn were not reactive for IgM. The mothers whose treatment was inadequate had IgM titers positive in 82.3% and their children had IgM positive in 11.8%. No correlation was found between a positive maternal IgM titer and the risk of the infant to present the disease. The newborn IgM titer is a useful parameter for an early diagnosis but a negative result cannot discard this pathology.
dc.fechaingreso.objetodigital2024-03-22
dc.fuente.origenORCID-ene24
dc.identifier.doi10.4067/S0716-10182000000400002 
dc.identifier.issn0716-1018
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-14044263220&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81021
dc.information.autorucEscuela de Medicina; Salazar Jofré, Aurora Rosa; S/I; 2451
dc.information.autorucEscuela de Medicina; García Canete, Patricia Del Carmen; 0000-0002-3817-4896; 73909
dc.information.autorucFacultad de Ciencias Biológicas; Goycoolea Montt, Manuela; S/I; 60903
dc.issue.numero4
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final296
dc.pagina.inicio289
dc.revistaRevista Chilena de Infectologia
dc.rightsacceso abierto
dc.subjectCongenital
dc.subject Diagnosis
dc.subjectLaboratory tests
dc.subjectSyphilis
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleEvaluación de métodos diagnósticos para sífilis congénita
dc.title.alternativeEvaluation of diagnostic methods for congenital syphilis
dc.typeartículo
dc.volumen17
sipa.codpersvinculados2451
sipa.codpersvinculados73909
sipa.codpersvinculados60903
sipa.trazabilidadORCID;2024-01-15
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
art02.pdf
Size:
40.83 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas