The Uterine Placental Bed Renin-Angiotensin System in Normal and Preeclamptic Pregnancy

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dc.contributor.authorAnton, Lauren
dc.contributor.authorMerrill, David C.
dc.contributor.authorNeves, Liomar A. A.
dc.contributor.authorDiz, Debra I.
dc.contributor.authorCorthorn, Jenny
dc.contributor.authorValdes, Gloria
dc.contributor.authorStovall, Kathryn
dc.contributor.authorGallagher, Patricia E.
dc.contributor.authorMoorefield, Cheryl
dc.contributor.authorGruver, Courtney
dc.contributor.authorBrosnihan, K. Bridget
dc.date.accessioned2025-01-21T00:08:14Z
dc.date.available2025-01-21T00:08:14Z
dc.date.issued2009
dc.description.abstractPreviously, we demonstrated activation of the renin-angiotensin system in the fetal placental chorionic villi, but it is unknown whether the immediately adjacent area of the maternal uterine placental bed is regulated similarly. This study measured angiotensin peptides, renin-angiotensin system component mRNAs, and receptor binding in the fundus from nonpregnant subjects (n = 19) and in the uterine placental bed from normal (n = 20) and preeclamptic (n = 14) subjects. In the uterine placental bed from normal pregnant women, angiotensin II peptide levels and angiotensinogen, angiotensin-converting enzyme, angiotensin receptor type 1 (AT1), AT2, and Mas mRNA expression were lower as compared with the nonpregnant subjects. In preeclamptic uterine placental bed, angiotensin II peptide levels and renin and angiotensin-converting enzyme mRNA expression were significantly higher than normal pregnant subjects. The AT2 receptor was the predominant receptor subtype in the nonpregnant fundus, whereas all angiotensin receptor binding was undetectable in normal and preeclamptic pregnant uterine placental bed compared with nonpregnant fundus. These findings suggest that the maternal uterine placental bed may play an endocrine role by producing angiotensin II, which acts in the adjacent placenta to vasoconstrict fetal chorionic villi vessels where we have shown previously that AT1 receptors predominate. This would lead to decreased maternal-fetal oxygen exchange and fetal nutrition, a known characteristic of preeclampsia. (Endocrinology 150: 4316-4325, 2009)
dc.fuente.origenWOS
dc.identifier.doi10.1210/en.2009-0076
dc.identifier.eissn1945-7170
dc.identifier.issn0013-7227
dc.identifier.urihttps://doi.org/10.1210/en.2009-0076
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95661
dc.identifier.wosidWOS:000269159800038
dc.issue.numero9
dc.language.isoen
dc.pagina.final4325
dc.pagina.inicio4316
dc.revistaEndocrinology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Uterine Placental Bed Renin-Angiotensin System in Normal and Preeclamptic Pregnancy
dc.typeartículo
dc.volumen150
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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