DIFFERENTIAL ASSOCIATION AND DISTRIBUTION OF ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE WITHIN RAT-LIVER SUBCELLULAR ORGANELLES

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dc.contributor.authorPERELMAN, A
dc.contributor.authorABEIJON, C
dc.contributor.authorHIRSCHBERG, CB
dc.contributor.authorINESTROSA, NC
dc.contributor.authorBRANDAN, E
dc.date.accessioned2025-01-23T19:23:21Z
dc.date.available2025-01-23T19:23:21Z
dc.date.issued1990
dc.description.abstractRat liver cholinesterases were found to share properties and characteristics with those expressed in cholinergic tissues. The distribution and presence of different molecular forms of cholinesterases in different subcellular organelles of rat liver were studied. The rough and smooth endoplasmic reticulum and Golgi apparatus were enriched in the G4 molecular form of acetylcholinesterase (AChE) (relative to the G2 molecular form), while the inverse was found in the plasma membrane. The interaction of these molecular forms of AChE with the Golgi membrane was studied in detail. Approximately one-half of the G4 form was free within the lumen while the remainder was an intrinsic membrane protein; all the G2 molecular form was anchored to the membrane via phosphatidylinositol. Only the G1 and G2 molecular forms of butyrylcholinesterase (BuChE) were found in the above subcellular organelles; both molecular forms were soluble within the lumen of Golgi vesicles. These results indicate that rat liver expresses several molecular forms of AChE which have multiple interactions with membranes and that liver is unlikely to be the source of the G4 form of BuChE present in high concentration in the plasma.
dc.fuente.origenWOS
dc.identifier.eissn1083-351X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99199
dc.identifier.wosidWOS:A1990CF66200035
dc.issue.numero1
dc.language.isoen
dc.pagina.final220
dc.pagina.inicio214
dc.revistaJournal of biological chemistry
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDIFFERENTIAL ASSOCIATION AND DISTRIBUTION OF ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE WITHIN RAT-LIVER SUBCELLULAR ORGANELLES
dc.typeartículo
dc.volumen265
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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