VARIATIONS IN UTERINE KALLIKREIN DURING CYCLE AND EARLY-PREGNANCY IN THE RAT

Simple item page
dc.contributor.authorCORTHORN, J
dc.contributor.authorVALDES, G
dc.date.accessioned2024-01-10T12:10:49Z
dc.date.available2024-01-10T12:10:49Z
dc.date.issued1994
dc.description.abstractWe have previously demonstrated the presence of tissue kallikrein and its mRNA in rat uterus, and an increase of the immunoreactive enzyme on Day 7 of gestation, which suggests a hormonal regulation and a role in implantation. This study pursued the sequential variations during the cycle and early pregnancy. During the estrous cycle, immunoreactive uterine kallikrein levels showed a recurrent pattern, with the highest value on proestrus (12.9 +/- 1.5 ng/uterus or 0.49 +/- 0.03 ng/mg protein), and the lowest on metestrus (4.1 ng +/- 0.5 ng or 0.30 +/- 0.03 ng/mg protein); p < 0.05. During gestation, values on Day 1 (6.1 +/- 0.4 ng/uterus or 0.30 +/- 0.01 ng/mg protein) and Day 3 (4.9 +/- 0.3 ng or 0.35 +/- 0.01 ng/mg protein) were similar to levels during estrus and diestrus; a progressive rise, observed from Day 5 (8.2 +/- 1.1 ng or 0.43 +/- 0.02 ngl mg protein), attained the highest value on Day 7 (15.8 +/- 1.7 ng or 0.78 +/- 0.05 ng/mg protein); p < 0.05. The variations observed during the cycle and early gestation coincide with those described for ovarian steroids and uterine vasoactive changes, suggest the hormonal regulation of uterine kallikrein levels, and support its role in implantation.
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1095/biolreprod50.6.1261
dc.identifier.eissn1529-7268
dc.identifier.issn0006-3363
dc.identifier.pubmedidMEDLINE:8080914
dc.identifier.urihttps://doi.org/10.1095/biolreprod50.6.1261
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76608
dc.identifier.wosidWOS:A1994NM63000008
dc.information.autorucMedicina;Valdes G;S/I;98654
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1264
dc.pagina.inicio1261
dc.publisherOXFORD UNIV PRESS INC
dc.revistaBIOLOGY OF REPRODUCTION
dc.rightsacceso restringido
dc.subjectARACHIDONIC-ACID RELEASE
dc.subjectDECIDUAL CELL REACTION
dc.subjectGLANDULAR KALLIKREIN
dc.subjectGENE FAMILY
dc.subjectMAST-CELLS
dc.subjectIMPLANTATION
dc.subjectBRADYKININ
dc.subjectBLOOD
dc.subjectHISTAMINE
dc.subjectPEPTIDES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleVARIATIONS IN UTERINE KALLIKREIN DURING CYCLE AND EARLY-PREGNANCY IN THE RAT
dc.typeartículo
dc.volumen50
sipa.codpersvinculados98654
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Variations in uterine kallikrein during cycle and early-pregnancy in the rat.pdf
Size:
2.61 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas