Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study

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dc.contributor.authorPham, Tai
dc.contributor.authorPesenti, Antonio
dc.contributor.authorBellani, Giacomo
dc.contributor.authorRubenfeld, Gordon
dc.contributor.authorFan, Eddy
dc.contributor.authorBugedo, Guillermo
dc.contributor.authorLorente, Jose Angel
dc.contributor.authorFernandes, Antero do Vale
dc.contributor.authorVan Haren, Frank
dc.contributor.authorBruhn, Alejandro
dc.contributor.authorRios, Fernando
dc.contributor.authorEsteban, Andres
dc.contributor.authorGattinoni, Luciano
dc.contributor.authorLarsson, Anders
dc.contributor.authorMcAuley, Daniel F.
dc.contributor.authorRanieri, Marco
dc.contributor.authorThompson, B. Taylor
dc.contributor.authorWrigge, Hermann
dc.contributor.authorBrochard, Laurent J.
dc.contributor.authorLaffey, John G.
dc.date.accessioned2025-01-20T22:15:12Z
dc.date.available2025-01-20T22:15:12Z
dc.date.issued2021
dc.description.abstractBackground: Current incidence and outcome of patients with acute hypoxaemic respiratory failure requiring mechanical ventilation in the intensive care unit (ICU) are unknown, especially for patients not meeting criteria for acute respiratory distress syndrome (ARDS).
dc.description.abstractMethods: An international, multicentre, prospective cohort study of patients presenting with hypoxaemia early in the course of mechanical ventilation, conducted during four consecutive weeks in the winter of 2014 in 459 ICUs from 50 countries (LUNG SAFE). Patients were enrolled with arterial oxygen tension/inspiratory oxygen fraction ratio <= 300 mmHg, new pulmonary infiltrates and need for mechanical ventilation with a positive end-expiratory pressure of >= 5 cmH(2)O. ICU prevalence, causes of hypoxaemia, hospital survival and factors associated with hospital mortality were measured. Patients with unilateral versus bilateral opacities were compared.
dc.description.abstractFindings: 12 906 critically ill patients received mechanical ventilation and 34.9% with hypoxaemia and new infiltrates were enrolled, separated into ARDS (69.0%), unilateral infiltrate (22.7%) and congestive heart failure (CHF; 8.2%). The global hospital mortality was 38.6%. CHF patients had a mortality comparable to ARDS (44.1% versus 40.4%). Patients with unilateral-infiltrate had lower unadjusted mortality, but similar adjusted mortality compared to those with ARDS. The number of quadrants on chest imaging was associated with an increased risk of death. There was no difference in mortality comparing patients with unilateral-infiltrate and ARDS with only two quadrants involved.
dc.description.abstractInterpretation: More than one-third of patients receiving mechanical ventilation have hypoxaemia and new infiltrates with a hospital mortality of 38.6%. Survival is dependent on the degree of pulmonary involvement whether or not ARDS criteria are reached.
dc.description.funderEuropean Society of Intensive Care Medicine
dc.fuente.origenWOS
dc.identifier.doi10.1183/13993003.03317-2020
dc.identifier.eissn1399-3003
dc.identifier.issn0903-1936
dc.identifier.urihttps://doi.org/10.1183/13993003.03317-2020
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94500
dc.identifier.wosidWOS:000670910500005
dc.issue.numero6
dc.language.isoen
dc.revistaEuropean respiratory journal
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOutcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study
dc.typeartículo
dc.volumen57
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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