A global point prevalence survey of antimicrobial use in neonatal intensive care units: The no-more-antibiotics and resistance (NO-MAS-R) study

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dc.contributor.authorPrusakov, Pavel
dc.contributor.authorGoff, Debra A.
dc.contributor.authorWozniak, Phillip S.
dc.contributor.authorCassim, Azraa
dc.contributor.authorScipion, Catherine E. A.
dc.contributor.authorUrzua, Soledad
dc.contributor.authorRonchi, Andrea
dc.contributor.authorZeng, Lingkong
dc.contributor.authorLadipo-Ajayi, Oluwaseun
dc.contributor.authorAviles-Otero, Noelia
dc.contributor.authorUdeigwe-Okeke, Chisom R.
dc.contributor.authorMelamed, Rimma
dc.contributor.authorSilveira, Rita C.
dc.contributor.authorAuriti, Cinzia
dc.contributor.authorBeltran-Arroyave, Claudia
dc.contributor.authorZamora-Flores, Elena
dc.contributor.authorSanchez-Codez, Maria
dc.contributor.authorDonkor, Eric S.
dc.contributor.authorKekomaki, Satu
dc.contributor.authorMainini, Nicoletta
dc.contributor.authorTrochez, Rosalba Vivas
dc.contributor.authorCasey, Jamalyn
dc.contributor.authorGraus, Juan M.
dc.contributor.authorMuller, Mallory
dc.contributor.authorSingh, Sara
dc.contributor.authorLoeffen, Yvette
dc.contributor.authorTamayo Perez, Maria Eulalia
dc.contributor.authorFerreyra, Gloria Isabel
dc.contributor.authorLima-Rogel, Victoria
dc.contributor.authorPerrone, Barbara
dc.contributor.authorIzquierdo, Giannina
dc.contributor.authorCernada, Maria
dc.contributor.authorStoffella, Sylvia
dc.contributor.authorEkenze, Sebastian Okwuchukwu
dc.contributor.authorde Alba-Romero, Concepcion
dc.contributor.authorTzialla, Chryssoula
dc.contributor.authorPham, Jennifer T.
dc.contributor.authorHosoi, Kenichiro
dc.contributor.authorConsuegra, Magdalena Cecilia Calero
dc.contributor.authorBetta, Pasqua
dc.contributor.authorHoyos, O. Alvaro
dc.contributor.authorRoilides, Emmanuel
dc.contributor.authorNaranjo-Zuniga, Gabriela
dc.contributor.authorOshiro, Makoto
dc.contributor.authorGaray, Victor
dc.contributor.authorMondi, Vito
dc.contributor.authorMazzeo, Danila
dc.contributor.authorStahl, James A.
dc.contributor.authorCantey, Joseph B.
dc.contributor.authorMonsalve, Juan Gonzalo Mesa
dc.contributor.authorNormann, Erik
dc.contributor.authorLandgrave, Lindsay C.
dc.contributor.authorMazouri, Ali
dc.contributor.authorAvila, Claudia Alarcon
dc.contributor.authorPiersigilli, Fiammetta
dc.contributor.authorTrujillo, Monica
dc.contributor.authorKolman, Sonya
dc.contributor.authorDelgado, Veronica
dc.contributor.authorGuzman, Veronica
dc.contributor.authorAbdellatif, Mohamed
dc.contributor.authorMonterrosa, Luis
dc.contributor.authorTina, Lucia Gabriella
dc.contributor.authorYunis, Khalid
dc.contributor.authorBelzu Rodriguez, Marco Antonio
dc.contributor.authorLe Saux, Nicole
dc.contributor.authorLeonardi, Valentina
dc.contributor.authorPorta, Alessandro
dc.contributor.authorLatorre, Giuseppe
dc.contributor.authorNakanishi, Hidehiko
dc.contributor.authorMeir, Michal
dc.contributor.authorManzoni, Paolo
dc.contributor.authorNorero, Ximena
dc.contributor.authorHoyos, Angela
dc.contributor.authorArias, Diana
dc.contributor.authorSanchez, Ruben Garcia
dc.contributor.authorMedoro, Alexandra K.
dc.contributor.authorSanchez, Pablo J.
dc.date.accessioned2025-01-20T22:24:09Z
dc.date.available2025-01-20T22:24:09Z
dc.date.issued2021
dc.description.abstractBackground: Global assessment of antimicrobial agents prescribed to infants in the neonatal intensive care unit (NICU) may inform antimicrobial stewardship efforts.
dc.description.abstractMethods: We conducted a one-day global point prevalence study of all antimicrobials provided to NICU infants. Demographic, clinical, and microbiologic data were obtained including NICU level, census, birth weight, gestational/chronologic age, diagnoses, antimicrobial therapy (reason for use; length of therapy), antimicrobial stewardship program (ASP), and 30-day in-hospital mortality.
dc.description.abstractFindings: On July 1, 2019, 26% of infants (580/2,265; range, 0-100%; median gestational age, 33 weeks; median birth weight, 1800 g) in 84 NICUs (51, high-income; 33, low-to-middle income) from 29 countries (14, high-income; 15, low-to-middle income) in five continents received >= 1 antimicrobial agent (92%, antibacterial; 19%, antifungal; 4%, antiviral). The most common reasons for antibiotic therapy were "rule-out" sepsis (32%) and "culture-negative" sepsis (16%) with ampicillin (40%), gentamicin (35%), amikacin (19%), vancomycin (15%), and meropenem (9%) used most frequently. For definitive treatment of presumed/confirmed infection, vancomycin (26%), amikacin (20%), and meropenem (16%) were the most prescribed agents. Length of therapy for culture-positive and "culture-negative" infections was 12 days (median; IQR, 8-14) and 7 days (median; IQR, 5-10), respectively. Mortality was 6% (42%, infection-related). An NICU ASP was associated with lower rate of antibiotic utilization (p = 0.02).
dc.description.abstractInterpretation: Global NICU antibiotic use was frequent and prolonged regardless of culture results. NICU-specific ASPs were associated with lower antibiotic utilization rates, suggesting the need for their implementation worldwide. (C) 2021 The Authors. Published by Elsevier Ltd.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.eclinm.2021.100727
dc.identifier.eissn2589-5370
dc.identifier.urihttps://doi.org/10.1016/j.eclinm.2021.100727
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94714
dc.identifier.wosidWOS:000645894000018
dc.language.isoen
dc.revistaEclinicalmedicine
dc.rightsacceso restringido
dc.subjectGlobal point prevalence study
dc.subjectNeonatal infection
dc.subjectNeonatal antimicrobial stewardship
dc.subjectAntibiotics
dc.subjectAntifungal
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA global point prevalence survey of antimicrobial use in neonatal intensive care units: The no-more-antibiotics and resistance (NO-MAS-R) study
dc.typeartículo
dc.volumen32
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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