NON-COMPETITIVE-NON-EQUILIBRIUM ALPHA-ADRENOCEPTOR BLOCKING PROPERTIES OF N-BENZYL IODOACETAMIDE, BETSAMIDE

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dc.contributor.authorHUIDOBROTORO, JP
dc.contributor.authorHUIDOBRO, F
dc.contributor.authorMIRANDA, H
dc.date.accessioned2025-01-23T19:44:37Z
dc.date.available2025-01-23T19:44:37Z
dc.date.issued1979
dc.description.abstractN-Benzyl iodoacetamide, betsamide, at 10 mg/kg i.v. blocked the hypertensive and contractile responses of the nictitating membrane of the cat to adrenaline [epinephrine]. The blockade had a lag period before full development. Pretreatment of cats with betsamide for 7 or 18 h showed a non-equilibrium type of .alpha.-adrenoceptor blockade. The responses of the nictitating membrane to adrenaline were markedly depressed and did not recover after high doses of adrenaline. In the same cats, adrenaline caused a profound hypotension. The effect of betsamide lasted for at least 72 h. In the rat isolated vas deferens, 3 .times. 10-5 M betsamide non-competitively blocked the contractile responses to noradrenaline [norepinephrine], the adrenoceptor blockade was less effective when betsamide was applied with noradrenaline. The blockade lasted for > 24 h and was not reversible after extensive washing. Betsamide antagonized the contractile effects of the guinea pig trachea to adrenaline and isoprenaline. Results are discussed in relation to a probable mechanism of action.
dc.fuente.origenWOS
dc.identifier.eissn2042-7158
dc.identifier.issn0022-3573
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100082
dc.identifier.wosidWOS:A1979HK45100004
dc.issue.numero9
dc.language.isoen
dc.pagina.final597
dc.pagina.inicio593
dc.revistaJournal of pharmacy and pharmacology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNON-COMPETITIVE-NON-EQUILIBRIUM ALPHA-ADRENOCEPTOR BLOCKING PROPERTIES OF N-BENZYL IODOACETAMIDE, BETSAMIDE
dc.typeartículo
dc.volumen31
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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