EVIDENCE FOR MORPHINE AND MORPHINE-LIKE ALKALOID RESPONSES RESISTANT TO NALOXONE BLOCKADE IN THE RAT VAS-DEFERENS

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dc.contributor.authorMIRANDA, H
dc.contributor.authorHUIDOBRO, F
dc.contributor.authorHUIDOBROTORO, JP
dc.date.accessioned2025-01-23T19:44:34Z
dc.date.available2025-01-23T19:44:34Z
dc.date.issued1979
dc.description.abstractThe application of morphine or surrogates to the isolated rat was deferens maintained at 37.degree. C in Tyrode solution produced an increase in the electrically induced muscular twitch. Leucine enkephal in or D-2-D-Ala-Met enkephalinamide produced a dose-dependent inhibition of the muscular twitch. The effect of morphine and derivatives was not antagonized by naloxone, but the depression caused by the opiate pentapeptides or .beta.-endorphin was readily antagonized and reversed by naloxone. Tolerance developed to the in vitro effect of morphine; vasa deferentia obtained from tolerant-dependent rats were about 6 .times. less sensitive to the effect of morphine and about 5 .times. less sensitive to the depression caused by leucine enkephalin as compared to their respective paired, placebo implanted control rats.
dc.fuente.origenWOS
dc.identifier.eissn1879-0631
dc.identifier.issn0024-3205
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100076
dc.identifier.wosidWOS:A1979GU80100011
dc.issue.numero16
dc.language.isoen
dc.pagina.final1518
dc.pagina.inicio1511
dc.revistaLife sciences
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEVIDENCE FOR MORPHINE AND MORPHINE-LIKE ALKALOID RESPONSES RESISTANT TO NALOXONE BLOCKADE IN THE RAT VAS-DEFERENS
dc.typeartículo
dc.volumen24
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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