Exercise Induces an Augmented Skeletal Muscle Mitochondrial Unfolded Protein Response in a Mouse Model of Obesity Produced by a High-Fat Diet

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dc.contributor.authorApablaza, Pia
dc.contributor.authorBorquez, Juan Carlos
dc.contributor.authorMendoza, Rodrigo
dc.contributor.authorSilva, Monica
dc.contributor.authorTapia, Gladys
dc.contributor.authorEspinosa, Alejandra
dc.contributor.authorTroncoso, Rodrigo
dc.contributor.authorVidela, Luis A.
dc.contributor.authorJuretic, Nevenka
dc.contributor.authordel Campo, Andrea
dc.date.accessioned2025-01-20T20:15:59Z
dc.date.available2025-01-20T20:15:59Z
dc.date.issued2023
dc.description.abstractIncrease in body fat contributes to loss of function and changes in skeletal muscle, accelerating sarcopenia, a phenomenon known as sarco-obesity or sarcopenic obesity. Studies suggest that obesity decreases the skeletal muscle (SM)'s ability to oxidize glucose, increases fatty acid oxidation and reactive oxygen species production, due to mitochondrial dysfunction. Exercise improves mitochondrial dysfunction in obesity; however, it is not known if exercise regulates the mitochondrial unfolded protein response (UPRmt) in the SM. Our study aimed to determine the mito-nuclear UPRmt in response to exercise in a model of obesity, and how this response is associated with the improvement in SM functioning after exercise training. C57BL/6 mice were fed a normal diet and high-fat diet (HFD) for 12 weeks. After 8 weeks, animals were subdivided into sedentary and exercised for the remaining 4 weeks. Grip strength and maximal velocity of mice submitted to HFD improved after training. Our results show an increase in the activation of UPRmt after exercise while in obese mice, proteostasis is basally decreased but shows a more pronounced increase with exercise. These results correlate with improvement in the circulating triglycerides, suggesting mitochondrial proteostasis could be protective and could be related to mitochondrial fuel utilization in SM.
dc.fuente.origenWOS
dc.identifier.doi10.3390/ijms24065654
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://doi.org/10.3390/ijms24065654
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92298
dc.identifier.wosidWOS:000957675000001
dc.issue.numero6
dc.language.isoen
dc.revistaInternational journal of molecular sciences
dc.rightsacceso restringido
dc.subjectobesity
dc.subjectUPRmt
dc.subjectskeletal muscle
dc.subjectexercise
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExercise Induces an Augmented Skeletal Muscle Mitochondrial Unfolded Protein Response in a Mouse Model of Obesity Produced by a High-Fat Diet
dc.typeartículo
dc.volumen24
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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