Central B-2 receptor involvement in the antinociceptive effect of bradykinin in rats

dc.contributor.authorPela, IR
dc.contributor.authorRosa, AL
dc.contributor.authorSilva, CAA
dc.contributor.authorHuidobroToro, JP
dc.date.accessioned2025-01-21T01:33:58Z
dc.date.available2025-01-21T01:33:58Z
dc.date.issued1996
dc.description.abstract1 The effect of intracerebroventricular (i.c.v.) injection of bradykinin (BK) and related peptides was tested on the dental pulp electrical stimulation threshold (DPEST) in rats.
dc.description.abstract2 BK (4, 8 and 16 nmol) induced a dose-dependent increase of DPEST, indicative of an antinociceptive effect.
dc.description.abstract3 I.c.v. injection of equimolar doses of BK-related peptides, Lys-BK and Met-Lys-BK, also induced an increase of DPEST, but the magnitude of the effect was not as intensive as that induced by BK, when the maximum increase of DPEST was considered. The peptide T-kinin induced a short lasting and weak antinociceptive effect.
dc.description.abstract4 The B-1 agonist, des-Arg(9)-BK (8 nmol) induced a significant antinociceptive effect, but this was not as intensive as that induced by BK.
dc.description.abstract5 The B-2 antagonist D-Arg(0)-Hyp(3)-Thi(5,8)-D-Phe(7)-BK (D-Arg(0)) competitively antagonized the BK-induced antinociception. Likewise, Hyp(3)-Thi(5,8)-D-Phe(7)-BK (Hyp) also antagonized BK effect. However, the compound Thi(5,8)-D-Phe(7)-BK (Thi), initially considered a pure BK antagonist, induced an antinociceptive effect, supporting previous observations that this peptide can also act as a partial agonist.
dc.description.abstract6 It is concluded that the dose-dependent antinociceptive effect induced by i.c.v. injection of BK is mediated by the stimulation of brain B-2 receptors.
dc.fuente.origenWOS
dc.identifier.issn0007-1188
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97497
dc.identifier.wosidWOS:A1996UY15700024
dc.issue.numero6
dc.language.isoen
dc.pagina.final1492
dc.pagina.inicio1488
dc.revistaBritish journal of pharmacology
dc.rightsacceso restringido
dc.subjectkinins
dc.subjectbradykinin
dc.subjectantinociceptive effect
dc.subjectB-1 receptor
dc.subjectB-2 antagonist
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCentral B-2 receptor involvement in the antinociceptive effect of bradykinin in rats
dc.typeartículo
dc.volumen118
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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