SNPs and taxane toxicity in breast cancer patients

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dc.contributor.authorBoso, Virginia
dc.contributor.authorJose Herrero, Mara
dc.contributor.authorSantaballa, Ana
dc.contributor.authorPalomar, Laura
dc.contributor.authorMegias, Juan E.
dc.contributor.authorde la Cueva, Helena
dc.contributor.authorRojas, Luis
dc.contributor.authorRemedios Marques, Maria
dc.contributor.authorLuis Poveda, Jose
dc.contributor.authorMontalar, Joaquin
dc.contributor.authorAlino, Salvador F.
dc.date.accessioned2025-01-23T21:40:47Z
dc.date.available2025-01-23T21:40:47Z
dc.date.issued2014
dc.description.abstractAim: In order to identify genetic variants associated with taxanes toxicity, a panel with 47 SNPs in 20 genes involved in taxane pathways was designed. Patients & methods: Genomic DNA of 113 breast cancer patients was analyzed (70 taking docetaxel, 43 taking paclitaxel). Results: Two SNPs associated with docetaxel toxicity were identified: CYP3A4*1B with infusion-related reactions; and ERCC1 Gln504Lys with mucositis (p <= 0.01). Regarding paclitaxel toxicity: CYP2C8 HapC and CYP2C8 rs1934951 were associated with anemia; and ERCC1 Gln504Lys with neuropathy (p <= 0.01). Conclusion: Genes involved in DNA repair mechanisms and reactive oxygen species levels influence taxane toxicity in cancer patients treated with chemotherapy schemes not containing platinum. These findings could lead to better treatment selection for breast cancer patients.
dc.description.funderLa Fe Institute for Health Research (IIS La Fe, Valencia, Spain)
dc.fuente.origenWOS
dc.identifier.doi10.2217/PGS.14.127
dc.identifier.eissn1744-8042
dc.identifier.issn1462-2416
dc.identifier.urihttps://doi.org/10.2217/PGS.14.127
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101629
dc.identifier.wosidWOS:000346235400002
dc.issue.numero15
dc.language.isoen
dc.pagina.final1858
dc.pagina.inicio1845
dc.revistaPharmacogenomics
dc.rightsacceso restringido
dc.subjectbreast neoplasms
dc.subjectdrug-related adverse reactions
dc.subjectgenetic polymorphism
dc.subjectpharmacogenetics
dc.subjecttaxoids
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSNPs and taxane toxicity in breast cancer patients
dc.typeartículo
dc.volumen15
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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