Wheat flour fortification with folic acid: Changes in neural tube defects rates in Chile

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dc.contributor.authorCortes, Fanny
dc.contributor.authorMellado, C.
dc.contributor.authorPardo, R. A.
dc.contributor.authorVillarroel, L. A.
dc.contributor.authorHertrampf, E.
dc.date.accessioned2024-01-10T13:09:57Z
dc.date.available2024-01-10T13:09:57Z
dc.date.issued2012
dc.description.abstractIn January 2000, Chilean Ministry of Health mandated the addition of folic acid (FA) to wheat flour in order to reduce the risk of neural tube defects (NTDs). This policy resulted in significant increases in serum and red cell folate in women of fertile age 1 year after fortification. To evaluate the effect of wheat flour fortification on the prevalence of NTDs in Chile we designed a prospective hospital-based surveillance program to monitor the frequency of NTDs in all births (live and stillbirths) with birth weight =500?g at the nine public maternity hospitals of Santiago, Chile from 1999 to 2009. During the pre-fortification period (19992000) the NTD rate was 17.1/10,000 births in a total of 120,566 newborns. During the post-fortification period (20012009) the NTD rate decreased to 8.6/10,000 births in a total of 489,915 newborns, which translates into a rate reduction of 50% (RR: 0.5; 95% CI: 0.420.59) for all NTDs. The rate reduction by type of NTD studied was: 50% in anencephaly (RR: 0.5; 95% CI: 0.380.67), 42% in cephalocele (RR: 0.58; 95% CI: 0.370.89), and 52% in spina bifida (RR: 0.48; 95% CI: 0.380.6). Rates showed significant reduction both in stillbirths and live births: 510.3 to 183.6/10,000 (RR?=?0.36; 95% CI: 0.250.53) and 13.3 to 7.5/10,000 (RR?=?0.56; 95% CI: 0.470.68), respectively. In Chile, fortification of wheat flour with FA has proven to be an effective strategy for the primary prevention of NTDs. (C) 2012 Wiley Periodicals, Inc.
dc.fechaingreso.objetodigital03-04-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/ajmg.a.35430
dc.identifier.eissn1552-4833
dc.identifier.issn1552-4825
dc.identifier.pubmedidMEDLINE:22711368
dc.identifier.urihttps://doi.org/10.1002/ajmg.a.35430
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77726
dc.identifier.wosidWOS:000306651400012
dc.information.autorucMedicina;Mellado C ;S/I;1002671
dc.information.autorucMatemática;Villarroel L;S/I;77182
dc.issue.numero8
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1890
dc.pagina.inicio1885
dc.publisherWILEY
dc.revistaAMERICAN JOURNAL OF MEDICAL GENETICS PART A
dc.rightsacceso restringido
dc.subjectneural tube defects
dc.subjectfolic acid
dc.subjectanencephaly
dc.subjectcephalocele
dc.subjectUNITED-STATES
dc.subjectSPINA-BIFIDA
dc.subjectPREVALENCE
dc.subjectREDUCTION
dc.subjectDECLINE
dc.subjectPREVENTION
dc.subjectVITAMIN
dc.subjectPROGRAM
dc.subjectIMPACT
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleWheat flour fortification with folic acid: Changes in neural tube defects rates in Chile
dc.typeartículo
dc.volumen158
sipa.codpersvinculados1002671
sipa.codpersvinculados77182
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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