Is cholecystectomy a real risk factor for Metabolic dysfunction-associated steatotic liver disease (MASLD)? A longitudinal cohort study from a population with a high burden of gallbladder diseases.

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dc.catalogadorjlo
dc.contributor.authorCorsi Sotelo, Óscar Felipe
dc.contributor.authorJara Jara, Constanza Andrea
dc.contributor.authorFernández, Magdalena
dc.contributor.authorPastore Thomson, Antonia
dc.contributor.authorPérez, Diego
dc.contributor.authorValdés Quezada, Alonso Esteban
dc.contributor.authorHuete Garin, Isidro Álvaro
dc.contributor.authorBriceño Valenzuela, Eduardo Andrés
dc.contributor.authorArab Verdugo, Juan Pablo
dc.contributor.authorBarrera Martínez, Francisco José
dc.contributor.authorArrese Jiménez, Marco Antonio
dc.contributor.authorCandia Balboa, Roberto Andrés
dc.date.accessioned2025-12-12T18:14:26Z
dc.date.available2025-12-12T18:14:26Z
dc.date.issued2025
dc.description.abstractBackground: : Cholecystectomy due to gallstones is one of the most frequent surgeries worldwide. Observational studies suggest that cholecystectomy may be a risk factor for metabolic dysfunction associated with steatotic liver disease (MASLD). However, gallstone disease and MASLD share common risk factors, which could make cholecystectomy a confounder.Aim: To assess the relationship among cholecystectomy, gallstones, and MASLD in a longitudinal cohort study from a population at high risk of gallbladder diseases.Methods: A longitudinal retrospective cohort study compared consecutive patients undergoing cholecystectomy with a control group composed of patients with their gallbladder intact. All participants had normal liver imaging and biochemistry at baseline. Participants with incomplete clinical records or significant alcohol consumption were excluded. The primary outcome was the development of MASLD after a follow-up of at least 3 years. Cox regression models were used to conduct multivariable analyses.Results: We included 427 participants 132 in the cholecystectomy group and 295 controls. The mean age was 47.2 years, with 71.7% being female, and 43.6% having gallstone disease. The median follow-up was 9.7 years.In the Cox multivariate analysis, male gender (aHR: 1.56 [1.09-2.24]), gallstone disease (aHR: 2.18 [1.42-3.36]), prediabetes (aHR: 1.56 [1.06-2.3]), diabetes (aHR: 2.39 [1.38-4.13]), and overweight/obesity (aHR: 5.7 [3.19-10.21]) were independent risk factors for MASLD. After adjustment, cholecystectomy was not associated with MASLD incidence (aHR: 0.68 [0.44-1.03]). Sensitivity analyses supported these findings.Conclusion: Cholecystectomy was not found to significantly influence the incidence of MASLD after adjusting formetabolic risk factors. The risk of developing MASLD is likely driven by metabolic factors and previous gallstone disease.
dc.format.extent8 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.clinre.2025.102732
dc.identifier.urihttps://doi.org/10.1016/j.clinre.2025.102732
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107388
dc.information.autorucEscuela de Medicina; Corsi Sotelo, Óscar Felipe; S/I; 187191
dc.information.autorucEscuela de Medicina; Jara Jara, Constanza Andrea; S/I; 1026012
dc.information.autorucEscuela de Medicina; Pastore Thomson, Antonia; S/I; 234544
dc.information.autorucEscuela de Medicina; Valdés Quezada, Alonso Esteban; S/I; 1089171
dc.information.autorucEscuela de Medicina; Huete Garin, Isidro Álvaro; 0000-0002-8746-1111; 731
dc.information.autorucEscuela de Medicina; Briceño Valenzuela, Eduardo Andrés; S/I; 18751
dc.information.autorucEscuela de Medicina; Arab Verdugo, Juan Pablo; 0000-0002-8561-396X; 132745
dc.information.autorucEscuela de Medicina; Barrera Martínez, Francisco José; 0000-0001-5334-1528; 14816
dc.information.autorucEscuela de Medicina; Arrese Jiménez, Marco Antonio; 0000-0002-0499-4191; 76095
dc.information.autorucEscuela de Medicina; Candia Balboa, Roberto Andrés; 0000-0003-1856-7737; 16705
dc.issue.numero10
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaClinics and Research in Hepatology and Gastroenterology
dc.rightsacceso restringido
dc.subjectMetabolic dysfunction-associated steatotic liver disease
dc.subjectCholecystectomy
dc.subjectGallbladder Diseases
dc.subject.ddc610
dc.titleIs cholecystectomy a real risk factor for Metabolic dysfunction-associated steatotic liver disease (MASLD)? A longitudinal cohort study from a population with a high burden of gallbladder diseases.
dc.typeartículo
dc.volumen49
sipa.codpersvinculados187191
sipa.codpersvinculados1026012
sipa.codpersvinculados234544
sipa.codpersvinculados1089171
sipa.codpersvinculados731
sipa.codpersvinculados18751
sipa.codpersvinculados132745
sipa.codpersvinculados14816
sipa.codpersvinculados76095
sipa.codpersvinculados16705
sipa.trazabilidadORCID;2025-12-09
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