THE EFFECT OF COMPLETE BILIARY OBSTRUCTION ON BILE SECRETION - STUDIES ON THE MECHANISMS OF POSTCHOLESTATIC CHOLERESIS IN THE RAT

Simple item page
dc.contributor.authorACCATINO, L
dc.contributor.authorCONTRERAS, A
dc.contributor.authorBERDICHEVSKY, E
dc.contributor.authorQUINTANA, C
dc.date.accessioned2025-01-23T19:44:23Z
dc.date.available2025-01-23T19:44:23Z
dc.date.issued1981
dc.description.abstractRats subjected to obstructive cholestasis apparently demonstrate in the postcholestatic period, after common duct obstruction release, a marked increase in canalicular bile flow relative to bile acid excretion. Changes in canalicular permeability and in (Na+-K+)-ATPase activity in isolated liver surface membranes were studied to determine whether they are associated with postcholestatic choleresis. The clearances of 14C-erythritol and 3H-inulin were simultaneously measured in rats subjected to a 3 day obstructive cholestasis and in controls, during spontaneous choleresis as well as during the i.v. infusion of sodium taurocholate at submaximal and saturating rates. In additional groups of bile duct-ligated rats and controls, liver surface membrane fractions were isolated and the activity of appropriate marker enzymes and (Na+-K+)-ATPase was determined. In the 2 groups 14C-erythritol clearance closely approximated total bile flow, suggesting that bile flow was of canalicular origin. Cholestatic rats showed a 6-fold increase in 3H-inulin clearance compared to controls. Canalicular permeability to inulin is apparently markedly increased in cholestatic rats. (Na+-K+)-ATPase activity was significantly higher in cholestatic rats than in controls in the homogenate (P < 0.001) and liver surface membranes, (P < 0.001). Enhanced choleretic response to bile acids in the postcholestatic period is associated with an increased permeability of canalicular structure to inulin and with a significant increase in homogenate and surface membrane (Na+-K+)-ATPase activity. Some important differences between bile secretory function of rats subjected to obstructive cholestasis and that described in models of bile secretory failure induced by drugs or monohydroxy-bile acids, are pointed out.
dc.fuente.origenWOS
dc.identifier.issn0022-2143
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100024
dc.identifier.wosidWOS:A1981LJ95800009
dc.issue.numero4
dc.language.isoen
dc.pagina.final534
dc.pagina.inicio525
dc.revistaJournal of laboratory and clinical medicine
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTHE EFFECT OF COMPLETE BILIARY OBSTRUCTION ON BILE SECRETION - STUDIES ON THE MECHANISMS OF POSTCHOLESTATIC CHOLERESIS IN THE RAT
dc.typeartículo
dc.volumen97
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas