Impact of respiratory distress syndrome in very low birth weight infants: a multicenter South-American study

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dc.catalogadorcarga
dc.contributor.authorFehlmann, Elisa
dc.contributor.authorTapia, Jose L.
dc.contributor.authorFernandez, Rocio
dc.contributor.authorBancalari, Aldo
dc.contributor.authorFabres, Jorge
dc.contributor.authorD'Apremont, Ivonne
dc.contributor.authorGarcia Zattera Maria Jose
dc.contributor.authorGrandi, Carlos
dc.contributor.authorCeriani Cernadas, Jose M.
dc.contributor.authorGrp Colaborativo Neocosur
dc.date.accessioned2025-09-15T10:30:11Z
dc.date.available2025-09-15T10:30:11Z
dc.date.issued2010
dc.description.abstractObjective. To analyze the incidence, risk factors, major morbidity, mortality and resource employment in very low birth weight infants (< 1500 g) with respiratory distress syndrome (RDS).
dc.description.abstractMethods. Descriptive study using prospectively obtained on-line information from a data base of 20 units belonging to the South American Neocosur Network. A total of 5991 VLBW infants were registered during years 2002-2007.
dc.description.abstractResults. The mean gestacional age was 29.1 weeks (95% CI 29.06-29.21) and the mean of birth weight was 1100.5 g (95% CI 1093.79-1107.37). The global incidence of RDS was 74% (95% CI 73-75). Antenatal steroids were administered to 73% of this population. The main risk factor was lower gestational age (p< 0.001); where as prenatal steroids (OR: 0.59; 95% CI 0.49-0.72), female gender (OR: 0.77; 95% CI 0.67-0.89) and premature rupture of membranes (OR: 0.81; 95% CI 0.68-0.96) were protective factors. Antenatal steroids was also associated with a decrease in mortality in those infants that presented with RDS (OR: 0.40; 95% CI 0.34-0.47). Use of resources was higher in the group with RDS, with a greater use of surfactant (74.3% vs. 7.3%, p< 0.001), mechanical ventilation (82.1% vs. 23.8%, p< 0.001), and more days of oxygen (median of 8 vs. 1 day, p< 0.001) and hospitalization (median of 61 vs. 45 days, p< 0.001). RDS was associated to an increase risk in the incidence of ROP, PDA, late onset sepsis, severe IVH and oxygen requirement at 36 weeks of corrected gestational age.
dc.description.abstractConclusions. RDS had a high incidence in very low birth weight infants, despite the frequent use of antenatal steroids. VLBW Infants with RDS had a higher mortality and an increase risk of relevant morbidity. RDS also increased use of resources.
dc.description.funderANILLO Project Statistics for Public Policy in Education: Analysis and Decision Making of Observational Data from the Chilean government
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.proenv.2015.05.002
dc.identifier.eisbn978-1-4665-1432-4
dc.identifier.eissn1668-3501
dc.identifier.issn0325-0075
dc.identifier.pubmedidMEDLINE:21132227
dc.identifier.urihttps://doi.org/10.1016/j.proenv.2015.05.002
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/105686
dc.identifier.wosidWOS:000282757800008
dc.information.autorucFacultad de Matemáticas; Garcia Zattera Maria Jose; S/I; 14903
dc.issue.numero5
dc.language.isoes
dc.pagina.final400
dc.pagina.inicio393
dc.publisherCRC PRESS-TAYLOR & FRANCIS GROUP
dc.relation.ispartofSpatial Statistics Conference, JUN 09-12, 2015, Avignon, FRANCE
dc.revistaARCHIVOS ARGENTINOS DE PEDIATRIA
dc.rightsregistro bibliográfico
dc.subjectvery low birth weight infants
dc.subjectrespiratory distress syndrome
dc.subjectantenatal steroids
dc.subjectmorbidity
dc.subjectmortality
dc.subjectrisk factors
dc.subjectSURFACTANT
dc.subjectNETWORK
dc.subjectOUTCOMES
dc.subjectDISEASE
dc.titleImpact of respiratory distress syndrome in very low birth weight infants: a multicenter South-American study
dc.typeartículo
dc.volumen108
sipa.codpersvinculados14903
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadWOS-SCOPUS;2025-09-15
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