Effect of substituents and chain length in amino-1,4-naphthoquinones on glutathione-S-transferase inhibition: molecular docking and electrochemical perspectives: a structure-activity study

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dc.contributor.authorFaundes, Judith
dc.contributor.authorMunoz-Osses, Michelle
dc.contributor.authorMorales, Pilar
dc.contributor.authorTasca, Federico
dc.contributor.authorZuniga Loyola, Cesar
dc.contributor.authorFaundez, Mario
dc.contributor.authorMascayano, Carolina
dc.contributor.authorIbacache, Juana A.
dc.date.accessioned2025-01-20T21:01:34Z
dc.date.available2025-01-20T21:01:34Z
dc.date.issued2022
dc.description.abstractIn this study, new homodimers and monoamination products based on the pharmacophore amino-1,4-naphthoquinone were synthesized. To perform a structure-activity study, three precursor quinones (2,3-dichloro-1,4-naphthoquinone, 1,4-naphthoquinone, and 2-hydroxy-1,4-naphthoquinone) and four diamines (4,40-diaminodiphenylmethane, 4,40-ethylenedianiline, ethylenediamine and 1,3-diaminopropane) were used. The reactions of the compounds were accomplished in the presence or the absence of Lewis acid as a catalyst. The new derivatives were evaluated as potential inhibitors of the enzyme glutathione-S-transferase (GST) by conjugating reduced glutathione (GSH) with the substrate 1-chloro-2,4-dinitrobenzene (CDNB). The study of the GST activity showed a clear structure-activity relationship in which the chlorinated compound 8 was the best inhibitor, with inhibition percentage values of 57%, being in the inhibition range as other GST inhibitors such as hexachlorophene and ethacrynic acid. These experimental results are consistent with molecular docking studies which show that compound 8 binds to the enzyme close to the catalytic site (G-site) and the chlorine group shows up to be essential for the stability of the ligand. Additionally, from the in silico exploration, a directly proportional trend between lipophilicity and enzyme affinity was noted, correlating with the experimental results of GST activity where the chlorine atom contributes positively to it. Finally, the electrochemical characterization provided another significant insight: the compounds with higher formal potential values (E-0) had the electron-withdrawing group chlorine being the most active against GST.
dc.fuente.origenWOS
dc.identifier.doi10.1039/d2nj04079d
dc.identifier.eissn1369-9261
dc.identifier.issn1144-0546
dc.identifier.urihttps://doi.org/10.1039/d2nj04079d
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92913
dc.identifier.wosidWOS:000877621600001
dc.issue.numero45
dc.language.isoen
dc.pagina.final21659
dc.pagina.inicio21648
dc.revistaNew journal of chemistry
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffect of substituents and chain length in amino-1,4-naphthoquinones on glutathione-S-transferase inhibition: molecular docking and electrochemical perspectives: a structure-activity study
dc.typeartículo
dc.volumen46
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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