Profile of adult patients hospitalized with COVID-19 before and after introduction of SARS-CoV-2 vaccinesPerfil de pacientes adultos hospitalizados por COVID-19 antes y después de la introducción de las vacunas contra SARS-CoV-2

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dc.article.numberem2357
dc.contributor.authorPotin M.
dc.contributor.authorAljaro S.
dc.contributor.authorLopez S.
dc.contributor.authorUauy O.
dc.contributor.authorCifuentes C.
dc.contributor.authorCerda J.
dc.contributor.authorValenzuela D.
dc.contributor.otherCEDEUS (Chile)
dc.date.accessioned2025-05-01T10:33:23Z
dc.date.available2025-05-01T10:33:23Z
dc.date.issued2023
dc.description.abstract© 2023, Sociedad Chilena de Infectologia. All rights reserved.Background: During the COVID-19 pandemic, the early prioriti-zation of SARS-CoV-2 vaccines for older adults may have affected the characteristics of hospitalized COVID-19 patients over time. Aim: To compare the clinical characteristics and outcomes of adult patients admitted for COVID-19 before (PER1) and after (PER2) the initiation of mass vaccination for SARS-CoV-2. Methods: Data on age, gender, comorbidities, complications, and outcomes of adult patients hospitalized for COVID-19 in a private clinic of Santiago, Chile, were collected. Scores for COVID-19 severity and nutritional risk were calculated. Results: In PER2, patients were younger but had similar comorbidities, except for a higher prevalence of overweight and obesity compared to PER1. Unvaccinated COVID-19 patients in PER2 required more invasive ventilatory support (38.9% vs. 14.3%, p = 0.03) and had a higher severity score (six) than vaccinated patients (five, p = 0.048). The variables that best predicted mortality were age ≥ 60 years (OR 28,995) and the presence of nutritional risk (OR 5,246). Discussion: Changes in the profile and outcomes of hospitalized patients during the COVID-19 pandemic are associated with the prioritization of SARS-CoV-2 vaccines and their protective effect in reducing hospitalizations and disease severity in older adults.
dc.description.funderChilean National Fund for Scientific and Technological Development Fondecyt, Iniciacion Grant
dc.format.extent18 páginas
dc.fuente.origenScopus
dc.identifier.doi10.4067/s0716-10182023000500472
dc.identifier.eisbn9780128194706
dc.identifier.eissn1422-0067
dc.identifier.isbn9783031764011
dc.identifier.issn07161018
dc.identifier.pubmedid40156360
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85178894290
dc.identifier.urihttps://doi.org/10.4067/s0716-10182023000500472
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103997
dc.identifier.wosidWOS:001126163600007
dc.information.autorucEscuela de Medicina; Potin Santander Marcela Patricia; 0000-0003-4985-4579; 64027
dc.information.autorucEscuela de Medicina; Cerda Lorca Jaime Rodrigo; 0000-0003-3463-8304; 3935
dc.information.autorucEscuela de Medicina; Valenzuela Suarez Andres Daniel; S/I; 163741
dc.issue.numero21
dc.language.isoes
dc.nota.accesoContenido parcial
dc.pagina.final480
dc.pagina.inicio472
dc.publisherSpringer
dc.relation.ispartofIntersections Interdisciplinary Research on Architecture, Design, City and Territory
dc.revistaRevista Chilena de Infectologia
dc.rightsacceso restringido
dc.subjectadults
dc.subjectcomorbidities
dc.subjectCOVID-19 vaccines
dc.subjectmortality
dc.subjectnutritional risk score
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleProfile of adult patients hospitalized with COVID-19 before and after introduction of SARS-CoV-2 vaccinesPerfil de pacientes adultos hospitalizados por COVID-19 antes y después de la introducción de las vacunas contra SARS-CoV-2
dc.typeartículo
dc.volumen40
sipa.codpersvinculados64027
sipa.codpersvinculados3935
sipa.codpersvinculados163741
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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