The Adaptor Protein-1 μ1B Subunit Expands the Repertoire of Basolateral Sorting Signal Recognition in Epithelial Cells

Simple item page
dc.contributor.authorGuo, Xiaoli
dc.contributor.authorMattera, Rafael
dc.contributor.authorRen, Xuefeng
dc.contributor.authorChen, Yu
dc.contributor.authorRetamal, Claudio
dc.contributor.authorGonzalez, Alfonso
dc.contributor.authorBonifacino, Juan S.
dc.date.accessioned2025-01-24T00:07:29Z
dc.date.available2025-01-24T00:07:29Z
dc.date.issued2013
dc.description.abstractAn outstanding question in protein sorting is why polarized epithelial cells express two isoforms of the mu 1 subunit of the AP-1 clathrin adaptor complex: the ubiquitous mu 1A and the epithelial-specific mu 1B. Previous studies led to the notion that mu 1A and mu 1B mediate basolateral sorting predominantly from the trans-Golgi network (TGN) and recycling endosomes, respectively. Using improved analytical tools, however, we find that mu 1A and mu 1B largely colocalize with each other. They also colocalize to similar extents with TGN and recycling endosome markers, as well as with basolateral cargoes transiting biosynthetic and endocytic-recycling routes. Instead, the two isoforms differ in their signal-recognition specificity. In particular, mu 1B preferentially binds a subset of signals from cargoes that are sorted basolaterally in a mu 1B-dependent manner. We conclude that expression of distinct mu 1 isoforms in epithelial cells expands the repertoire of signals recognized by AP-1 for sorting of a broader range of cargoes to the basolateral surface.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.devcel.2013.10.006
dc.identifier.eissn1878-1551
dc.identifier.issn1534-5807
dc.identifier.urihttps://doi.org/10.1016/j.devcel.2013.10.006
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101917
dc.identifier.wosidWOS:000327417200012
dc.issue.numero3
dc.language.isoen
dc.pagina.final366
dc.pagina.inicio353
dc.revistaDevelopmental cell
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Adaptor Protein-1 μ1B Subunit Expands the Repertoire of Basolateral Sorting Signal Recognition in Epithelial Cells
dc.typeartículo
dc.volumen27
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas